脑胶质瘤PI3K信号通路的研究进展  

Progress in PI3K Pathway of Glioma

作　　者：韩磊[1] 浦佩玉[1] 康春生[1] 

机构地区：[1]天津医科大学总医院神经外科/天津市神经病学研究所,天津300052

出　　处：《中国神经肿瘤杂志》2010年第1期39-43,共5页Chinese Journal of Neuro-Oncology

基　　金：国家自然科学基金资助(30772231;30971136);教育部新世纪优秀人才支持计划资助(NCET-07-0615);天津市科技计划项目资助(09JCZDJC17600);天津市卫生局科学基金资助(09KZ112)

摘　　要：脑胶质瘤是最常见的颅内原发性肿瘤,因多数呈浸润性生长,治疗效果不佳,寻找有效的治疗手段势在必行。目前研究表明,胶质瘤的恶性进展涉及信号转导通路的异常,这为开辟新的治疗手段提供了新思路。现已初步证实,磷酸磷脂酰肌醇-3-羟基激酶信号转导通路异常与胶质瘤的发生、发展关系最为密切,故本文着重对该通路的相关内容作简要介绍。Gliomas are the most common primary intracranial tumors.The current therapies are unsatisfactory because of infiltrating growth of gliomas.Therefore,more effective treatments need to be developed.However,the discoveries of cellular signaling pathway abnormality in gliomas provided the important information in the searching for more effective treatment on gliomas.It has been shown that the abnormality of signaling pathway mediated by phosphoinositol-3-OH-kinase is closely correlated with the development and malignant progression of gliomas.Therefore,we briefly reviewed the role of PI3K pathway in gliomas in this article.

关 键 词：胶质瘤 信号转导通路 磷酸磷脂酰肌醇-3-羟基激酶 

分 类 号：R739.41[医药卫生—肿瘤]