COX-2 mRNA在宫颈腺癌组织中的表达及临床意义  

The expression and clinical significance of COX-2 mRNA in adenocarcinoma of the uterine cervix

作　　者：刘岿然[1] 赵敏[2] 张淑兰[2] 

机构地区：[1]中国医科大学附属盛京医院第一妇科病房,辽宁省沈阳100004 [2]中国医科大学附属盛京医院妇产科,辽宁省沈阳100004

出　　处：《中国医师杂志》2010年第11期1445-1447,共3页Journal of Chinese Physician

基　　金：2008年辽宁省高等学校科研项目计划（NO2008862）,2009年中华医学科技奖叁等奖（NO 200903124P0806）

摘　　要：目的 检测COX-2 mRNA在正常宫颈及宫颈腺癌组织中的表达情况,探讨其在宫颈腺癌发病机制中的作用.方法 采用RT-PCR方法,检测COX-2在36例宫颈腺癌组织及15例正常宫颈组织中的表达.结果 宫颈腺癌组织中COX-2-mRNA的阳性检出率为55.6%,明显高于正常宫颈组织20.0%,差异有统计学意义（P＜0.05）,COX-2 mRNA的表达随宫颈腺癌期别及病理分级的升高而增加,但各期别和各病理分级之间差异无统计学意义（P＞0.05）.结论 宫颈腺癌组织中存在COX-2过表达,COX-2的过表达与宫颈腺癌的发生有关.Objective To detect COX-2 mRNA in cervical cancer and normal cervix, and explore the pathogenesis of adenocarcinoma of the uterine cervix. Methods COX-2 expression was detected by RT-PCR to explore the relationship between COX-2 and the adenocarcinogenon of cervical cancer in 36 cases of adenocarcinoma of the uterine cervix and 15 cases normal cervical tissue. Results The positive rate of COX-2 mRNA in adenocarcinoma of the uterine cervix tissues （55.6%） was higher than that of normal tissues （ 20. 0% ）, the difference was significant （ P ＜ 0. 05）. The expression of COX-2 mRNA was associated with stages and clinical grading of tumor （ P ＜ 0. 05）, but no significant difference was found between stages and clinical grading of uterine cervix adenocarcinoma（ P ＞ 0. 05）. Conclusion The hyper expression of COX-2 mRNA in uterine cervix adenocarcinoma took part in the carcinogenesis of tumor.

关 键 词：前列腺素内过氧化物合酶类/代谢 宫颈肿瘤/代谢 

分 类 号：R737.33[医药卫生—肿瘤]