结肠癌中P73和Survivin的表达及临床意义  

Expression of p73 and its correlation with Survivin in colon carcinoma

作　　者：卢笛[1] 付云辉[2] 

机构地区：[1]湖南省人民医院消化内科,长沙410005 [2]江西省萍乡市人民医院

出　　处：《中国医师杂志》2010年第11期1482-1484,共3页Journal of Chinese Physician

摘　　要：目的 探讨P73和Survivin在结肠癌中的表达及临床意义.方法 应用免疫组化方法检测46例结肠癌组织、12例正常结肠黏膜组织中P73及Survivin的表达.结果 结肠癌与正常结肠黏膜组织中P73阳性表达率分别为67.4%和8.3%,二者阳性率表达比较差异有统计学意义（χ2=13.42,P＜0.01）;淋巴结转移灶组的P73阳性率明显高于结肠癌原发灶组（P＜0.01）,P73表达与结肠癌的Dukes分期有关（χ2=8.01,P＜0.01）.P73与Survivin在结肠癌中的表达呈正相关（rs=0.487,P＜0.01）.结论 P73与Survivin在结肠癌中的表达密切相关,其参与了结肠癌的发生及发展,可作为判断其转移及预后的参考指标.Objective To study the expression of P73 and its relationship with expression of Survivin in colon carcinoma. Methods The expression of P73 and Survivin was studied by immunohistochemical technique in 46 cases of colon carcinoma and 12 cases of normal colon mucosa. Results The P73 expression rate of colon carcinoma was significant higher than that of normal colon mucosa（χ2 = 13.42, P ＜0.01 ）. Overexpression of P73 was related to the pathological grade and Dukes stage （ （ χ2 = 8.01, P ＜0.01 ）, and it was closely related to lymphatic metastasis of colon carcinoma（ P ＜0.01 ）. There was a positive relation between P73 and Survivin（ rs =0.487, P ＜0.01 ）. Conclusions The expression of P73 was closely associated with Survivin in colon carcinoma. The results suggested that the overexpression of P73 and Survivin was involved in the tumorigenesis and development of colon carcinoma and P73 and Survivin might be used as a new tumor marker in metastasis and prognosis of colon carcinoma.

关 键 词：结肠肿瘤/代谢 微管相关蛋白质类/代谢 DNA结合蛋白质类/代谢 核蛋白质类/代谢 

分 类 号：R735[医药卫生—肿瘤]