超排卵是促进卵泡同步化还是放大卵泡发育不同步?  

Dose controlled ovarian stimulation promote synchronization or unsynchronization of follicle development?

作　　者：孙莹璞[1] 董方莉[1] 

机构地区：[1]郑州大学第一附属医院生殖医学中心,郑州450052

出　　处：《生殖医学杂志》2010年第A01期26-29,共4页Journal of Reproductive Medicine

摘　　要：从自然周期取卵进行体外受精一胚胎移植（IVF—ET）获得第一例试管婴儿诞生，至采用超排卵成功，其后相关的衍生技术迅速发展，尤其是控制性卵巢刺激（controlled ovarian stimulation，COS）方案的改进使得在同一个取卵周期中多个卵泡发育，获得成熟卵率增高，补偿了取卵、IVF操作中每个环节的丢失，增加移植优质胚胎的机会，从而提高临床妊娠率。目前，COS方案有多种，不同的方案有不同的适应证，本文从COS方案是促进卵泡同步化还是放大卵泡发育不同步进行阐述。In in vitro fertilization and embryo transfer （IVF-ET）, controlled ovarian stimulation （COS） program is usually used to synchronize follicular development, increase oocyte maturation rate, and improve pregnancy rate. There are now several different protocols in COS program, including gonadotro- pin-releasing hormone agonist （GnRH-a） long protocol, short protocol and gonadotropin-releasing hor- mone antagonist （GnRH-ant） protocol. All COS programs are expected to promote synchronization of follicular development and maturation. However, the development of a few follicles in COS are not syn- chronized. To avoid the unsynchronization of follicular development, the commonly used methods are dominant follicle puncture, corticosteroids pretreatment or GnRH-ant pretreatment. Individualized protocols for superovulation can improve the synchronization of follicular development and subsequently retrieve more high-quality oocytes for IVF-ET.

关 键 词：控制性卵巢刺激 同步化 卵泡发育 促性腺激素释放激素激动剂 促性腺激素释放激素拮抗剂 

分 类 号：R[医药卫生]