血液流变学指标和全血组织因子活性检测在慢性脑血管病中的意义  

Significance of detecting hemorheological parameters and whole blood tissue factor activity in chronic cerebrovascular disease

作　　者：董明国[1] 杜忠芳[1] 程静[1] 石应元[1] 严蜀华[1] 魏文宁[2] 

机构地区：[1]武汉科技大学附属天佑医院检验科,武汉市430064 [2]华中科技大学附属协和医院微循环室,武汉市430030

出　　处：《中华实用诊断与治疗杂志》2010年第12期1189-1190,1194,共3页Journal of Chinese Practical Diagnosis and Therapy

摘　　要：目的:探讨血液流变学指标和组织因子促凝活性指标对慢性脑血管病早期诊断和疗效监测的作用。方法:对77例慢性脑血管病患者(慢性脑血管病组)和40例健康体检者(对照组)检测全血黏度等6项参数及组织因子促凝活性,并比较2组各项指标变化情况。结果:慢性脑血管病组患者全血黏度等6项指标及组织因子促凝活性均较对照组高(P<0.05)。治疗后血液流变学指标有明显改善,其中红细胞聚集指数、纤维蛋白原和组织因子促凝活性降低明显(P<0.01)。结论:血液流变学指标和组织因子促凝活性对慢性脑血管病早期诊断及治疗效果判断具有重要临床意义。Objective To investigate the significance of hemorheological analysis and tissue factor procoagulant activity in the early diagnosis and curative effect monitor of chronic cerebrovascular disease.Methods Six parameters including whole blood viscosity and tissue factor procoagulant activity were detected in 77 cases of chronic cerebrovascular disease and 40 healthy controls to compare the changes between two groups.Results The Six parameters were higher in chronic cerebrovascular disease group than those in control group,which showed significant differences（P0.05）.The hemorheological parameters were significantly lowered in chronic cerebrovascular disease after treatment,especially red blood cell aggregation,fibrinogen and tissue factor procoagulant activity（P0.01）.Conclusion The hemorheological parameters and tissue factor procoagulant activity play important roles in the early diagnosis and curative effect monitor of chronic cerebrovascular disease.

关 键 词：慢性脑血管病 血液流变学 全血组织因子促凝活性 

分 类 号：R743.3[医药卫生—神经病学与精神病学]