表鬼臼素对慢性致癫幼鼠海马结构的影响  

Effect of podophyllotoxin on hippocampal formation in immature rats with status epilepticus

作　　者：张志强[1] 杨金升[1] 石向群[1] 尹榕[1] 李天真[1] 

机构地区：[1]兰州军区兰州总医院,甘肃兰州730050

出　　处：《西北国防医学杂志》2010年第6期439-441,共3页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的:探讨幼鼠早期癫痫持续状态与成鼠后海马硬化的关系;探讨表鬼臼素对海马硬化的影响。方法:采用锂-匹罗卡品腹腔注射制成幼鼠癫痫持续状态模型,应用Timm组织化学染色方法观察苔藓纤维发芽情况。结果:表鬼臼素干预组海马结构的损害与匹罗卡品对照组一致,苔藓纤维发芽现象较匹罗卡品组轻。结论:幼鼠早期长时间的痫性发作与成鼠后海马硬化有关;表鬼臼素对海马硬化的发生可能有抑制作用。Objective： To investigate the relationship between status epilepticus （ SE） in early immature rats and hippocampal sclerosis in their mature rats,and to observe the protective effect of podophyllotoxin on hippocampal sclerosis. Methods： Rats were injected Lithium-pilocarpine intrapentoneally to establish a temporal lobe epilepsy model. Timm histochemical technique was adopted to study mossy fiber sprouting. Results： The podophyllotoxin interferential group had the same hippocampal formation damage with the Lithium-pilocarpine group,while the mossy fiber sprouting was less. Conclusion： The prolonged seizure in early immature rats was related with the hippocampal formation of mature rats,and podophyllotoxin may have protective effects to hippocampal sclerosis.

关 键 词：癫痫 表鬼臼素 海马结构 苔藓纤维发芽 氯化锂-匹罗卡品 WISTAR大鼠 

分 类 号：R742.1[医药卫生—神经病学与精神病学]