中国大陆汉族人卡马西平过敏性药疹与HLA-B*1502的关联性分析  

Association between HLA-B*1502 Allele and Carbamazepine-Induced Cutaneous Adverse Reactions in Han People of China Mainland

作　　者：王倩[1] 周珏倩[1] 周列民[1] 陈子怡[1] 杨丽白[1] 陈树达[1] 方子妍[1] 蔡晓冬[1] 戴启麟[1] 

机构地区：[1]中山大学附属第一医院神经科,广东广州510080

出　　处：《中山大学学报（医学科学版）》2010年第6期828-832,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省科技计划项目(2007B0315102004;2009B060700108

摘　　要：【目的】探讨我国大陆地区汉族人群中HLA-B*1502与卡马西平引起的过敏性药疹的关联性。【方法】收集48例卡马西平过敏性药疹患者,其中9例为重型过敏性药疹患者(包括Stevens-Johnson综合征、中毒性表皮坏死松解症),39例为轻型过敏性药疹患者;以及80例服用卡马西平无过敏患者和62例正常对照者,采用PCR-SSP法进行HLA-B*1502的基因型测定,观察卡马西平引起过敏性药疹与HLA-B*1502基因型是否存在关联。【结果】卡马西平重型过敏性药疹组HLA-B*1502基因型携带率为100%,显著高于卡马西平无过敏组(13.75%)及正常对照组(17.74%),差异均具有统计学意义(P<0.001)。卡马西平轻型过敏性药疹组HLA-B*1502基因型携带率与卡马西平无过敏组(25.64%vs.13.75%,P=0.110)及正常对照组(25.64%vs.17.74%,P=0.341)比较,差异均无统计学意义。【结论】我国大陆地区汉族人群中,卡马西平引起的重型过敏性药疹与HLA-B*1502基因型具有高度关联性。尚未发现卡马西平引起的轻型过敏性药疹与HLA-B*1502基因型有关联。【Objective】 To explore weather HLA-B＊1502 allele is associated with carbamazepine-induced cutaneous adverse reactions in Han people of China mainland. 【Methods】 HLA-B＊1502 allele genotyping was performed by a polymerase chain reaction-sequence specific primers （PCR-SSP） method on 48 Han Chinese subjects who had carbamazepine-induced cutaneous adverse reactions,including 9 severe cutaneous adverse reaction patients with Stevens-Johnson syndrome （SJS） or Toxic epidermal necrolysis （TEN） and 39 cutaneous adverse reaction patients with maculopapular eruption （MPE）,and 80 carbamazepine-tolerant controls,62 normal individuals. 【Results】 The frequency of HLA-B＊1502 allele among SJS / TEN patients （100%） is significantly higher than HLA-B＊1502 allele among carbamazepine-tolerant controls （13.75%,P 0.001） and normal individuals （17.74%,P 0.001）. But neither the frequency between MPE patients and carbamazepine-tolerant controls （25.64% vs. 13.75%,P = 0.110）,nor the frequency between MPE patients and normal individuals （25.64% vs. 17.74%,P = 0.341）,have any significant difference. 【Conclusions】 The data showed that HLA-B＊1502 allele is associated with carbamazepine-induced SJS / TEN but not MPE in Han people of China mainland.

关 键 词：人类白细胞抗原HLA-B＊1502 基因 卡马西平 重型过敏性药疹 轻型斑丘疹 

分 类 号：R74[医药卫生—神经病学与精神病学]