T细胞淋巴瘤中MUM1蛋白的表达及其与细胞增殖的关系  

Expression of MUM1 protein in T-cell lymphoma and its relationship with cell proliferation

作　　者：王素芬[1] 黄卡特[1] 陈霖[1] 杨开颜[1] 

机构地区：[1]温州医学院附属第一医院病理科,浙江温州325000

出　　处：《癌变．畸变．突变》2010年第6期458-461,共4页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：目的:探讨T细胞淋巴瘤中MUM1蛋白的表达及其与肿瘤细胞增殖的关系。方法:收集诊断及分型均明确的T细胞淋巴瘤患者的石蜡包埋组织58例,其中T淋巴母细胞性淋巴瘤/白血病(precursor Tlymphoblastic lymphoma/leukemia,T-LBL/L)9例、间变性大细胞淋巴瘤(anaplastic large Tcell lymphoma,ALCL)12例和外周T细胞性淋巴瘤(peripheral Tcell lymphoma,PTL)37例。另选2例反应性增生性淋巴结炎组织作对照。应用免疫组织化学法检测各组织中MUM1蛋白、ki-67的表达,并分析肿瘤组织中MUM1蛋白表达与ki-67增殖指数的关系。结果:1例T-LBL/L(1/9,11.11%)、9例ALCL(9/12,75.0%)和26例PTL(26/37,70.27%)组织中MUM1蛋白的表达呈阳性。MUM1蛋白在T-LBL/L中的阳性表达率明显低于ALCL组和PTL组(P<0.05),而在ALCL与PTL间的差别无统计学意义(P>0.05)。MUM1蛋白阳性病例的ki-67增殖指数(53.61±23.83)%与MUM1阴性组(53.27±21.23)%相比,其差异无统计学意义(P>0.05)。结论:MUM1蛋白在T细胞淋巴瘤中的表达可能与细胞活化有关,与肿瘤细胞的增殖可能无直接关系。OBJECTIVE： To investigate the expression of MUM1 protein in T-cell lymphoma and its relationship with tumor cell proliferation.METHODS： The expressions of MUM1 protein and ki-67 in 58 specimens of T-NHL were analyzed by immunohistochemistry,including 9 cases of precursor T lymphoblastic lymphoma/leukemia（T-LBL/L）,12 cases of anaplastic large T cell lymphoma（ALCL） and 37 cases of peripheral T cell lymphoma（PTL）.Two cases of reactive hyperplastic lymphadenitis were used as comparison.We also analysed the relationship between MUM1 protein in tumor and ki-67 proliferation index.RESULTS： MUM1 protein expression was positive in 1 of 9 T-LBL/L,9 of 12 ALCL and 26 of 37 PTL by immunohistochemistry.The expression rate of MUM1 protein in T-LBL/L was significantly lower than that in ALCL and PTL（P0.05）.The expression rate of MUM1 protein was similar in ALCL and PTL（P0.05）.There was no significant difference in MUM1 positive group of ki-67 proliferation index（53.61±23.83）% compared with MUM1 negative group（53.27±21.23）%（P0.05）.CONCLUSION： The expression of MUM1 in T cell lymphoma may be associated with cell activation but not directly related to the proliferation of tumor cells.

关 键 词：T细胞淋巴瘤 MUM1蛋白 ki-67增殖指数 

分 类 号：R733[医药卫生—肿瘤]