端粒酶逆转录酶mRNA在口腔扁平苔藓中的表达  

Expression of telomerase reverse transcriptase mRNA in oral lichen planus

作　　者：程曼莉[1] 杨亦萍[1] 曹阳[1] 何克新[1] 

机构地区：[1]广西医科大学附属口腔医院口腔内科,南宁530021

出　　处：《口腔医学》2010年第11期655-657,共3页Stomatology

基　　金：自然科学基金项目(桂科自0640098)

摘　　要：目的探讨端粒酶逆转录酶(TERT)mRNA在口腔扁平苔藓(OLP)中的表达及临床意义。方法采用原位杂交(ISH)的方法,检测了20例糜烂型扁平苔藓(erosive oral lichen planus,eOLP)、20例非糜烂型扁平苔藓(non-erosive oral lichen planus,neOLP)和12例正常口腔黏膜TERT mRNA的表达。结果糜烂型OLP的TERT mRNA阳性率明显高于非糜烂型OLP的TERT mRNA阳性率(P<0.05)。糜烂型OLP与非糜烂型OLP染色强度相比有统计学意义(P<0.05)。结论糜烂型OLP的上皮细胞可能比非糜烂型OLP的上皮细胞处于更高的增殖状态。Objective To study the expression of telomerase reverse transcriptase mRNA in oral lichen planus and their clinical significance.Methods We detected the expression of TERT mRNA in 20 cases of erosive oral lichen planus,20 cases of non-erosive oral lichen planus and 12 normal oral mucosa by a RNA in situ hybridisation method.Results The positive expression rate of TERTmRNA was much higher in the erosive OLP than in the non-erosive OLP（P〈0.05）.There was a significant difference in the expression level of TERT mRNA between erosive OLPand non-erosive OLP（P〈0.05）.Conclusions Erosive OLP are in a higher state of proliferation than non-erosive OLP.

关 键 词：口腔扁平苔藓 端粒酶逆转录酶MRNA 增殖 

分 类 号：R781.5[医药卫生—口腔医学]