免疫表型为CD8^+,CD4^-,CD56^+的蕈样肉芽肿1例  

A Case Report of Mycosis Fungoides with phenotype of CD8^+,CD4^-,CD56^+

作　　者：甄希[1] 于建斌[1] 张江安[1] 徐文博[1] 庞丽娜[1] 曹瑞祥[1] 

机构地区：[1]郑州大学第一附属医院皮肤科,河南郑州450052

出　　处：《中国皮肤性病学杂志》2010年第12期1135-1137,共3页The Chinese Journal of Dermatovenereology

摘　　要：报告1例免疫表型为CD4-,CD8+,CD56+的蕈样肉芽肿(MF)。患者男,21岁。双侧腋窝、躯干及腹股沟大片状灰红色至棕红色斑8年,呈渐进性发展,无任何自觉症状。腹部皮损组织病理示表皮轻度角化不全,真皮内致密淋巴细胞,部分细胞入侵表皮。免疫组化示CD4-,CD8+,CD3+,CD43+,CD68灶状+,CD30灶状+,CD56+,TIA-1-,EBV-。诊断:蕈样肉芽肿。给予阿维A胶囊30mg/d,顿服,糠酸莫米松乳膏及多磺酸粘多糖乳膏外用。皮损缓解,临床随访4个月,病情稳定。A 21-year-old Chinese man was presented with progressive multiple brown reddish patches on bilateral axillary region,trunk and bilateral groin for 8 years. No symptom was complained. The pathological examination of abdominal skin lesions revealed apodeme disappeared,dermal dense infiltration of lymphocytes with some lymphoid cell infiltrated skin. The immunohistochemical staining showed CD8^＋,CD4^-,CD56^＋,TIA-1-,EBV-,CD3^＋,CD43^＋,CD68 focal^＋,CD30 focal^＋. Diagnosis of mycosis fungoides was made. the patient received a treatment of oral Acitretin Capsules 30mg/d and topical mometasone furoate cream plus the MPS cream for 4 months. Follow-up showed the patient was still in stable condition.

关 键 词：蕈样肉芽肿 免疫表型 CD4^- CD8^+ CD56^+ 

分 类 号：R739.5[医药卫生—肿瘤]