非酒精性脂肪肝调脂治疗的临床效果观察  

Observation on Clinical Effect of Cholesterol Lowering Treatment for Non-alcoholic Fatty Liver Disease(NAFLD)

作　　者：许会东[1] 蒋超[1] 

机构地区：[1]枣庄市立医院,山东枣庄277102

出　　处：《预防医学论坛》2010年第11期1020-1022,共3页Preventive Medicine Tribune

摘　　要：[目的]评价调脂治疗非酒精性脂肪肝(NAFLD)患者的疗效。[方法]选择2006年7月至2009年7月到枣庄市立医院健康查体确定为轻、中度NAFLD,但血脂水平分层标准在"合适范围"的患者100例,治疗组80例口服阿托伐他汀20 mg/d,疗程12周;对照组20例与治疗组均给予治疗性生活方式。连续观察12周。[结果]治疗12周与治疗前比较,治疗组血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)下降,高密度脂蛋白胆固醇(HDL-C)上升(P<0.01),对照组上述指标的差异均无统计学意义(P>0.05)。肝/脾CT比值,治疗组由0.70±0.23改善为0.91±0.25(P<0.01)。[结论]调脂治疗对于治疗非酒精性脂肪肝有明显的近期效果。[Objective] To evaluate the effect of cholesterol lowering treatment in NAFLD patients.[Methods]100 light or middle NAFLD patients were sampled with serum level standards in ＂appropriate range＂ medically examined in Zaozhuang city Hospital from July 2006 to July 2009.80 of them as treatment group were given oral atorvastatin 20 mg/d with a period of treatment for 12 weeks;20 of them as control group were given the same treated life style as those in treatment group.Observe for 12 weeks continuously.[Results]Compared with pre-treatment,after 12-week treatment,the treatment group＇s TC,LDL-C,TG decreased,while HDL-C increased（P〈0.01）,the control group＇s index differences have no statistic significance（P〉0.05）.The ratio of liver to spleen by CT improved from（0.70±0.23） to（0.91±0.25）（P〈0.01）.[Conclusion]Cholesterol lowering treatment has obvious short-term effect on treating NAFLD.

关 键 词：非酒精性脂肪肝 调脂 效果 

分 类 号：R575.5[医药卫生—消化系统]