fMRI观察情绪记忆编码中的持续效应和瞬时效应  

Functional MRI in study of sustained and transient effects in encoding processes of emotional memory

作　　者：吴津民[1] 王海宝[1] 余永强[1] 潘志立[1] 柏亚[1] 胡孝朋[1] 宋文[1] 

机构地区：[1]安徽医科大学第一附属医院放射科,安徽合肥230022

出　　处：《中国医学影像技术》2010年第12期2243-2246,共4页Chinese Journal of Medical Imaging Technology

基　　金：安徽省自然科学基金(50430601);安徽省教育厅自然科学重点项目基金(KJ2010A186)

摘　　要：目的通过fMRI检测情绪记忆相关脑区激活情况,探讨情绪记忆编码中持续效应与瞬时效应脑机制,为进一步探讨情绪记忆障碍相关疾病的神经机制提供依据。方法 22名健康成人参加试验。试验材料为60幅负性情景(情绪记忆)和60幅中性情景图片。采用组块-事件相关混合设计模式。受试者在完成编码任务的同时接受fMRI扫描。利用SPM2和SPSS13.0分别对fMRI数据及行为学数据进行统计分析。结果情绪记忆(3.15±0.14)和中性(2.25±0.08)图片记忆成绩(d')差异有统计学意义(t=2.79,P=0.010)。fMRI结果显示,情绪记忆增强与内侧颞叶和前额叶不同亚区相关;右侧杏仁核(r=0.50,P=0.019)和眶额皮层(r=0.64,P=0.001)与持续效应显著相关,左侧杏仁核(r=0.65,P=0.001)和眶额皮层(r=0.65,P=0.001)与瞬时效应显著相关。结论情绪记忆编码中持续效应和瞬时效应具有不同的神经机制,分别与右侧和左侧杏仁核及眶额皮层相关。Objective To explore mechanisms of sustained and transient effects in encoding processes of emotional memory via examination of functional MRI （fMRI）,and to provide evidence for further understanding of the underlying neural mechanism related to emotional memory disorders. Methods Sixty negatively emotional pictures and 60 neutral scene pictures were used in the study. Twenty-two subjects participated in and mixed block/event-related design was adapted. fMRI scanning was performed while subjects conducted encoding tasks. SPM 2 and SPSS 13.0 statistical software were used,respectively. Results Differences of behavioral performance were significant （t=2.79,P=0.010） between emotional （3.15±0.14） and neutral （2.25±0.08） pictures. fMRI findings indicated that emotional enhancement of memory was associated with subcortices of medial temporal lobe and frontal lobe. The sustained effect was related to the right amygdala （r=0.50,P=0.019） and orbitofrontal cortex （r=0.64,P=0.001）,while the transient effect was correlated with the left amygdala （r=0.65,P=0.001） and orbitofrontal cortex （r=0.65,P=0.001）. Conclusion Different neural mechanisms are involved in sustained and transient effects of emotional memory encoding. Right amygdala and orbitofrontal cortex are responsible for sustained effect and the left ones are responsible for transient effect.

关 键 词：情绪记忆 持续效应 瞬时效应 杏仁核 磁共振成像 

分 类 号：R33[医药卫生—人体生理学] R445.2[医药卫生—基础医学]