紫外线照射液体输注疗法对兔脑缺血再灌注脑超微结构变化的作用  

Ultraviolet liquid irradiation therapy for ultrastructure change of cerebral ischemia re-perfusion in rabbits

作　　者：阎福岭[1,2] 李燕[1,2] 袁真丽[1,2] 方树友[1,2] 许予明[1,2] 

机构地区：[1]河南医科大学第一附属医院神经内科 [2]河南省人民医院神经内科

出　　处：《中华理疗杂志》1999年第3期148-149,共2页Chinese Journal of Physical Therapy

基　　金：河南省科委资助

摘　　要：目的：观察紫外线照射液体输注（ｕｌｔｒａｖｉｏｌｅｔｌｉｑｕｉｄｉｒａｄｉａｔｉｏｎ，ＵＤＩ）疗法对兔脑缺血再灌注脑组织超微结构改变的影响。方法：制作兔脑缺血再灌注模型，分组进行不同的处理，应用透射电镜观察脑组织病理改变。结果：脑缺血再灌注时神经细胞明显破坏；ＵＤＩ疗法或丹参均可减轻脑病理损害程度，经光量子化的丹参作用更显著。结论：ＵＤＩ疗法对缺血脑组织有明显的保护作用，且与丹参药物联合应用有协同功效。ＵＤＩ疗法脑保护作用的机制尚未完全明了，可能与改善花生四烯酸代谢、增加脑组织ＡＴＰ生成等作用有关。Objective: To observe the effect of ultraviolet(UV)liquid irradiation on ultrastructure change of rabbit's cerebral ischemia re-perfusion. Methods: The models were performed in 40 rabbits.Then,the glucose Sol.and radix salviae miltiorrhize(RSM) Sol.irradiated by UV was used to take part in experiment.Experimental rabbits were divided into four groups:Group 1 and group 2 rabbits were only driped(I.V) with simple glucose and RSM Sol.respectively.Group 3 and group 4 rabbits were separately treated with UV glucose and RSM Sol.irradiation therapy.After treatment,the cerebral pathology change was detected in each rabbit. Results: During the cerebral ischemia re-perfusion,there were obvious injuries of neurons.At post-UV liquid irradiation therapy,the ultrastructure injuries in brain were reduced,but the effect of RSM Sol.was more obvious. Conclusion: It is demonstrated that UV liquid irradiation therapy has a cooperation and protection effect for cerebral ischemia.Although the mechanism is unknown completely,it is possibly related to metabolism of arachidonic acid and enhence the cerebral ATP production.

关 键 词：脑缺血 再灌注 超微结构 UDI 光量子疗法 

分 类 号：R743.310.5[医药卫生—神经病学与精神病学] R454.2[医药卫生—临床医学]