氦氖激光照射对SP2/0骨髓瘤小鼠肿瘤坏死因子活性的影响  

Effect of He-Ne laser irradiation on tumor necrosis factor derived from mice with SP2/0 marrow tumor

作　　者：高美华[1] 冯献启[1] 宫照龙[1] 王海燕[1] 胡涛[1] 

机构地区：[1]山东省滨州市滨州医学院

出　　处：《中华理疗杂志》1999年第3期156-157,共2页Chinese Journal of Physical Therapy

基　　金：山东省教委资助

摘　　要：目的：采用激光增强荷瘤小鼠肿瘤坏死因子（ＴＮＦ）活性，增强瘤鼠抗肿瘤免疫功能。方法：将小鼠分为５组，其中Ⅱ～Ⅳ组为激光照射脾区的不同时间组，采用双抗体夹心酶标法观测激光照射脾区后荷瘤小鼠ＴＮＦ变化。结果：激光照射小鼠脾区后，Ⅱ～Ⅳ组的含量均较对照组（Ⅰ组）升高，差异均有非常显著性，Ｐ＜０．０１，说明激光作用于脾区具有促进ＴＮＦ产生的作用。结论：氦氖激光照射脾区具有增强ＴＮＦ活性及抗肿瘤效应。Objective: Using the laser to increase the activity of tumor necrosis factor(TNF) to enhence the tumor immune function. Methods: These etperimental rats were divided into five groups:Group - rats were radiated with laser at different time on spleen area. Double antibody sandwich enzyme linked immunosorbent assay(ELISA) was used to measure the TNF change in mice with tumor. Results: Laser acted on spleen region promoting TNF production.Laser groups showed significantly changes( P<0.01) compared with control group. Conclusion: He-Ne laser may enhance TNF activity and antitumor function.

关 键 词：骨髓瘤 激光疗法 氦氖激光照射 肿瘤坏死因子 

分 类 号：R733.305[医药卫生—肿瘤] R454.2[医药卫生—临床医学]