耳穴透穴埋针刺法治疗偏头痛的临床疗效及对血浆5-羟色胺含量的影响  

Effect of Otopoint-needle Embedment on Headache and Plasma 5-HT Content in Migraine Patients

作　　者：贾春生[1] 郑丽娅[2] 石晶[1] 马小顺[2] 李晓峰[2] 李文丽[2] 朱慧军[3] 

机构地区：[1]河北医科大学中医学院,石家庄050091 [2]河北医科大学基础课教学部,石家庄050091 [3]邢台市人民医院康复科,邢台054031

出　　处：《针刺研究》2010年第6期448-452,473,共6页Acupuncture Research

基　　金：河北省中医药管理局资助项目(No.200657)

摘　　要：目的:观察耳穴透穴埋针刺法治疗偏头痛的临床疗效及探讨其作用机制。方法:92例偏头痛患者按照就诊的先后顺序随机分为试验组和对照组,每组46例。试验组采用耳穴透穴埋针刺法,以额、颞、枕为主穴,伴有恶心、呕吐者加胃、交感,伴畏光者加眼,每次留针5 d,共埋针4次;对照组口服尼莫地平,40 mg/次,3次/d,连服4周。治疗结束后1个月和6个月分别评定两组近期疗效和远期疗效;采用荧光分光法检测两组治疗前后的血浆5-羟色胺(5-HT)含量。结果:治疗结束后1个月和6个月两组综合评分均低于治疗前(P<0.01);组间综合评分比较,试验组均低于对照组(P<0.01)。两组患者近期疗效比较,试验组总有效率82.61%(38/46),对照组总有效率67.39%(31/46),差异有统计学意义(P<0.05);两组患者远期疗效比较,试验组总有效率83.72%(36/43),对照组总有效率57.14%(24/42),差异有统计学意义(P<0.05)。治疗结束后两组血浆5-HT含量比较,试验组高于对照组(P<0.05)。结论:耳穴透穴埋针刺法是治疗偏头痛的一种有效方法,其作用机制可能与提高患者血浆5-HT含量有关。Objective To observe the effect of otopoint-needle embedment on migraine and to explore its underlying mechanism. Methods Ninety-two migraine outpatients were equally randomized into acupuncture group and medication group. For patients of the acupuncture group, one sterilized intradermal needle was inserted into E （MA-AT）-point and advanced toward Nie （Temple-point, MA-AT）, then another inserted into Nie（Temple-point, MA-AT） and advanced toward Zhen（Occipus-point, MA-AT）, followed by fixing the needles with a piece of adhesive-tape respectively, combined with Wei （Stomach-point, MA-IC）, Jiaogan （Sympathesis-point, MA-AH 7） for migraine patients with nausea and vomiting, and with Yan （Eye-point, MA-L 1） for those with phengophobia. Plasma serotonin （5-HT） contents before and after the treatment were detected by fluorescence spec- trophotometry. Results In comparison with the pre-treatment, the synthetic scores of two groups one month and 6 months after the treatment were decreased significantly （ P〈0.01 ）. The integrative sores of the acupuncture group one month and 6 months after the treatment were significantly lower than those of the medication group （P〈0.01 ）. The total effective rates of recent efficacy and long-term efficacy of the acupuncture group were 82.61% （38/46） and 83.72% （36/43） respectively, being significantly higher than those E67.39% （31/46） and 57. 14% （24/42）1 of the medication group. After the treatment, plasma 5-HT content of the acupuncture group was remarkablely higher than that of the medication group （P〈0.05）. Conclusion Otopoint-needle implant can effectively relieve headache in migraine patients and upregulate plasma 5-HT level.

关 键 词：偏头痛 耳穴透穴埋针刺法 血浆5-羟色胺 

分 类 号：R245.323[医药卫生—针灸推拿学]