血小板胞浆钙离子与脑梗塞  

PLATELET CYTOPLASMIC CALCIUM AND STROKE

作　　者：韩恩吉[1,2] 韩淑英 

机构地区：[1]山东医科大学附属医院神经内科 [2]山东省淄博市周村第二医院内科

出　　处：《山东医科大学学报》1999年第2期127-128,共2页Acta Academiae Medicinae Shandong

基　　金：世界卫生组织国际神经科学研究基金

摘　　要：为研究血小板活化程度与脑梗塞临床严重程度之间的关系，选择２６例健康对照者和３０例脑梗塞患者，以Ｍａｔｈｅｗ、Ｔｏｒｏｎｔｏ和Ｂａｒｔｈｅｌ计分代表临床严重程度，水母发光蛋白导入－凝胶过滤法测量血小板胞浆钙离子浓度。结果表明，脑梗塞组血小板胞浆钙离子浓度明显高于对照组，脑梗塞组是（２．８７±０．３５）μｍｏｌ／Ｌ，对照组是（２．０１±０．３１）μｍｏｌ／Ｌ，两组间有极显著差异（Ｐ＜０．００１）。血小板胞浆钙离子与３种临床计分之间均无明显相关性。脑梗塞组血小板胞浆钙离子明显升高，显示脑梗塞患者急性期血小板处于易激活状态。血小板胞浆钙离子与３种临床计分无明显相关，表明血小板活化指标不能预示临床严重程度。The relationship between platelet activation and stroke severity was studied. The stroke severity was shown in the clinical scores (Mathew, Toronto, and Barthel), the platelet cytoplasmic calcium was measured in Aequorinloaded and Gelfiltered platelets in 26 healthy controls and 30 patients with acute ischemic stroke. The results showed that platelet cytoplasmic calcium was significantly increased in the stroke patients as compared with controlsmol/L,control group (2.010.31)mol/L,P<0.001]. There was no statistically significant correlation between the platelet cytoplasmic calcium and the clinical scores. Increased level of platelet cytoplasmic calcium in stroke patients indicates that platelets in the acute phase of stroke are easily activated. No correlation between the platelet cytoplasmic calcium and the clinical scores shows that indicator of platelet activation does not presage the severity of stroke patient.

关 键 词：脑梗塞 血小板胞浆 钙离子 临床计分 

分 类 号：R743.33[医药卫生—神经病学与精神病学]