^(18)F-FDG PET/CT在乳腺癌术后肿瘤标志物升高中的价值  

THE VALUE OF ^(18)F-FDG PET/CT IN MONITORING PATIENTS WITH INCREASED TUMOR MAKERS AFTER BREAST CANCER SURGERY

作　　者：郭佳[1] 陈跃[1] 

机构地区：[1]泸州医学院附属医院核医学科,泸州646000

出　　处：《现代预防医学》2011年第1期186-187,189,共3页Modern Preventive Medicine

摘　　要：[目的]探讨18F-脱氧葡萄糖(Fluorine-18 fluorodeoxyglucose,FDG)正电子发射计算机断层显像(Positron Emission Computer Tomography,PET/CT)在乳腺癌术后肿瘤标志物(CA153,CA125,CEA)升高患者中的应用价值。[方法]对22例乳腺癌术后伴肿瘤标志物升高的患者临床资料进行回顾性分析,18F-FDGPET/CT全身显像探测有无复发或/和转移灶。[结果]18F-FDG PET/CT诊断阳性11例,其中1例经针吸病理证实为假阳性;18F-FDG PET/CT诊断阴性11例,经随访证实为真阴性。18F-FDG PET/CT诊断乳腺癌转移的灵敏度100%(10/10),特异性91.67%(11/12),阳性预测值90.91%(10/11),阴性预测值100%(11/11)。[结论]18F-FDG PET/CT显像能可靠地鉴别肿瘤标志物升高的乳腺癌术后患者有无转移或复发,准确探测复发和转移灶,改变治疗方案,是其他影像学方法和肿瘤标志物监测的重要补充。[Objective] To evaluate the value of ^18F-FDG PET/CT in monitoring patients with increased tumor makers after breast cancer surgery. [ Methods] 22 patients underwent chemoradiotherapy after operation with increased tumor makers （one or two or three） were performed ^18F-FDG PET/CT for monitonng recurrence or metastasis. Finally, the results of PET/CT imaging were proved by pathology and clinical follow-up. The duration of the clinical follow-up varied from 3 months to 7 months. [ Results ]^18F-FDG PET/CT diagnosed 11 positive, but one of the 11 was proven as false positive by needle sampling. ^18F-FDG PET/CT diagnosed the other 11 negative which were proven true negative by follow-up. The sensitivity, specificity, positive predictive value and negative predictive value obtained by ^18F-FDG PET/CT were 100% （10/10）, 91.67% （11/12）, 90.91% （10/11） and 100% （11/11）, respectively. [Conclusion] ^18F-FDG PET/GT imaging can reliably identify and detect recun＇ences or metastasis in breast cancer patients with increased tumor makers, change treatment plans. It can be the critical supplement of other imagang modalities and tumor makes.

关 键 词：正电子发射计算机断层显像 ^18F-氟代脱氧葡萄糖 乳腺癌 CA153 CA125 CEA 

分 类 号：R737.9[医药卫生—肿瘤]