血清泌乳素含量与乳腺癌关系的探讨  

Relationship Between Serum PRL and Breast Cancer

作　　者：关晏星[1] 雷秋模[1] 王莉[1] 张芸[1] 

机构地区：[1]江西医学院影像系核医学教研室 [2]南昌市第三医院

出　　处：《实用癌症杂志》1999年第2期90-92,共3页The Practical Journal of Cancer

摘　　要：为探讨血清泌乳素（ＰＲＬ）与乳腺癌发生、发展的关系。对１１７例乳腺增生病、３６例乳腺纤维腺瘤及５１例乳腺癌患者进行了血清ＰＲＬ含量的测定，对１７例乳腺癌及２１例纤维腺瘤患者进行了雌激素受体的测定。结果显示：轻度乳腺增生、早期乳腺癌患者血清ＰＲＬ含量与正常对照组比较无显著性差异（Ｐ＞０．０５），重度乳腺增生、瘤样增生及纤维腺瘤患者均较轻度增生者的血清ＰＲＬ含量增高（Ｐ＜０．０１）；不同期别的乳腺癌患者，其血清ＰＲＬ含量随期别的增加而显著增高（Ｐ＜０．０１）。提示血清ＰＲＬ含量增高是促进乳腺癌发展的重要因素。To study the relation between PRL contents and breast cancer,serum PRL and tissue ER contents in patients with hyperplasia fibroadenoma and breast carcinoma at different stages were measured by radioimmunoassay and radioligand binding assay.The results showed that higher PRL levels were found in patients with seriousdegree or liketumor hyperplasia and fibroadenoma compared with lightdegree hyperplasia and normal control group(P<0.05);There were higher ER and lower serum PRL contents in breast cancer than in fibroadenoma(P<0.01);PRL level of patients with breast cancer at different stages increased remarkably with development of the disease(P<0.01).It suggested that PRL increace is a very important factor for the development of breast cancer.

关 键 词：泌乳素 乳腺癌 乳腺增生病 血清 测定 

分 类 号：R737.9[医药卫生—肿瘤] R655.8[医药卫生—临床医学]