小胶质细胞表达的受体与阿尔采末病  

The receptors expression in microglia and Alzheimer's disease

作　　者：武冬慧[1,2] 胡金凤[1] 宋修云[1] 赵文杰[1] 陈乃宏[1] 

机构地区：[1]中国医学科学院北京协和医学院药物研究所,北京100050 [2]天津中医药大学,天津300193

出　　处：《中国药理学通报》2010年第12期1550-1553,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30973887);创新药物研究开发技术平台建设(No2009ZX09301;2009ZX09303)

摘　　要：阿尔采末病(Alzheimer's disease,AD)是一种老年神经退行性疾病,其病因十分复杂,其中β-淀粉样蛋白(Aβ)毒性学说、tau蛋白过度磷酸化学说、基因突变、中枢胆碱能损伤学说等已得到普遍认可。近年来,由小胶质细胞介导的炎症学说也越来越受到重视。小胶质细胞是脑内先天性免疫反应的主要部位,在外源因子的刺激下可以表达大量受体,如TLRs、NLRs、RAGE等,这些受体在AD的发展过程中起重要作用。该文就由小胶质细胞激活所表达的受体与阿尔采末病的关系做一综述。Alzheimer＇s disease（AD）is a degenerative disease in central nervous system with complicated pathologic causes which have not been clarified yet.At present,the most recognized hypothesized mechanisms include β-amyloid（Aβ）toxicity,abnormal phosphorylation of tau,gene mutation and damaged CNS choline system.For the past few years,the inflammation mediate by the microglia has received growing attention.Microglia mediates the mainly innate immunity in brain and generates a large number of receptors stimulated by exogenous factors,such as TLRs,NLRs and RAGE,which play an important role in the development of AD.This review is about the different receptors of microglia and AD.

关 键 词：小胶质细胞 受体 阿尔采末病 AΒ 炎症 神经退行性疾病 

分 类 号：R-05[医药卫生] R322.81