中国甘肃人群髓过氧化物酶基因多态性与急性白血病易感性的关系  

Relationship between Polymorphisms of Myeloperoxidase Gene and Susceptibility of Acute Leukemia in Chinese Gansu Population

作　　者：席亚明[1] 石秀娥[2] 李培[1] 张豪[1] 李明[1] 刘蓓[1] 姚小健[1] 徐建旺[1] 

机构地区：[1]甘肃省兰州大学第一医院血液科血液学研究所,甘肃兰州730000 [2]甘肃省康复中心医院老年病科,甘肃兰州730000

出　　处：《中国实验血液学杂志》2010年第6期1431-1434,共4页Journal of Experimental Hematology

基　　金：甘肃人群毒物代谢酶基因的遗传多态性与白血病易感性的相关研究基金资助(编号0708NKCA113)

摘　　要：本研究旨在探讨甘肃汉族人群髓过氧化物酶(myeloperoxidase,MPO)基因多态性和急性白血病易感性的关系。用1∶1配对病例-对照方法及LDR-PCR方法,对100例急性白血病(AL)患者和100例非血液病、非肿瘤者作为对照进行mpo基因G463A突变分析。结果发现,AL病例组mpo基因a等位基因频率(19%)和ga/aa基因型频率(31%)均低于对照组(28%和54%)。携带ga/aa基因型的个体发生AL的相对风险度为其野生型(gg)的0.383倍(95%CI=0.215-0.682)。进一步分层分析显示,急性髓系白血病(AML)病例组ga/aa基因型频率(28.2%)低于对照组(54%)(p<0.01)。携带ga/aa基因型的个体发生AML的相对风险度为其野生型(gg)的0.346倍(95%CI=0.157-0.546)。急性淋巴细胞白血病(ALL)病例组mpo基因a等位基因频率和ga/aa基因型频率均与对照组无统计学差异(p>0.05)。结论:本研究人群mpo基因多态性与AML遗传易感性相关,等位基因a对AML易感性有保护作用,但与ALL易感性无关联。This study was aimed to explore the relationship between gene polymorphisms of myeloperoxidase （MPO） and the susceptibility of acute leukemia in Chinese Gansu population. G463A mutation of mpo gene was analyzed by polymerase chain reaction-ligase detection reaction （PCR-LDR） in 100 normal individuals （control group） and 100 patients with acute leukemia （AL group）. The results showed that the a allele genotype and ga/aa genotype of mpo gene occurred more frequently in control group （28% and 54%） than those in AL group （19% and 31%） （p0.05）. The AL risk for controls was decreased by 0.383-fold,compared with the individuals with gg genotype （95% CI=0.215-0.682,p0.01）. By further stratified analysis,the ga/aa genotype of mpo gene occurred more frequently in control group （54%） than those in AML group （28.2%） （p0.01）. AML risk （95% CI=0.157-0.546,p0.01） in the controls was decreased by 0.346-fold compared with the individual with gg genotype,however,the acute lymphoblastic leukemia （ALL） showed no significant difference from control group in the incidence of the allele a genotype and ga/aa genotype of mpo gene. It is concluded that mpo gene polymorphism is associated with susceptibility of acute myeloid leukemia in Chinese Gansu population. The risk of AML decreases in the persons carrying a allele,but mpo gene polymorphism is not associated with susceptibility of acute lymphoblastic leukemia.

关 键 词：髓过氧化物酶 mpo基因 基因多态性 白血病易感性 急性白血病 

分 类 号：R733.7[医药卫生—肿瘤]