16例淋巴浆细胞淋巴瘤/华氏巨球蛋白血症临床特点  

Clinical Features of 16 Cases of Lymphoplasmacytic Lymphoma/Waldenstrm Macroglobulinemia

作　　者：王继军[1] 景红梅[1] 申红卫[2] 徐教生[3] 李敏[3] 高子芬[3] 克晓燕[1] 

机构地区：[1]北京大学第三医院血液内科,北京100191 [2]北方医院放射科,北京100700 [3]北京大学第三医院病理科,北京100191

出　　处：《中国实验血液学杂志》2010年第6期1494-1498,共5页Journal of Experimental Hematology

摘　　要：本研究旨在探讨淋巴浆细胞淋巴瘤/华氏巨球蛋白血症(lymphoplasmacytic lymphoma,LPL/Waldenstrm macroglobulinemia,WM)的临床特点、诊断及治疗方法。回顾性分析16例淋巴浆细胞淋巴瘤/华氏巨球蛋白血症患者的临床特点、骨髓细胞形态学及病理检查特点、治疗方法。结果表明:16例淋巴浆细胞淋巴瘤/华氏巨球蛋白血症患者的平均发病年龄为65.1岁,贫血和高粘综合征是最常见的表现;骨髓检查可见淋巴细胞、淋巴浆细胞或浆细胞增多;淋巴结活检可见瘤细胞弥漫分布,免疫组织化学检测显示表达B细胞相关抗原;经治疗后总反应率(overall response rate,ORR)81.3%,完全缓解25%,生存时间6-108月,其中3例死亡,生存率为81.3%。结论:淋巴浆细胞淋巴瘤/华氏巨球蛋白血症患者的疾病过程具有低度恶性B细胞淋巴瘤的特点,病程较长,经治疗可获缓解,但不易治愈,部分患者可转化为中高度恶性淋巴瘤。In order to investigate the clinical manifestations,diagnosis,therapy and prognosis of lymphoplasmacytic lymphoma/Waldenstrm macroglobulinemia（LPL/WM）,16 patients with LPL/WM were analyzed retrospectively. The results showed that the average age of 16 patients with LPL/WM was 65.1 years old,the most common syndromes were anemia and hyperviscosity syndrome,bone marrows were composed of small lymphocyte,admixed with variable numbers of plasma cells and plasmacytoid lymphocytes. And lymph node biopsy revealed that most cells expressed B-cell-associated antigen. Among the 16 cases,complete remission was 25%,overall response rate（ORR） was 81.3%,overall survival time was 6 to 108 months. 3 patients died and survival rate was 81.3 %. It is concluded that the clinical course of LPL/WM is typically indolent. These patients can acquire remission in clinic,but can not be cured,some of them can transform into patients with more malignant lymphoma.

关 键 词：淋巴浆细胞淋巴瘤 华氏巨球蛋白血症 临床特点 

分 类 号：R733.1[医药卫生—肿瘤]