4-1BBL分子在脑胶质瘤组织中的表达及其临床意义  

Clinical significance of 4-1BBL protein expression in human glioma tissues

作　　者：牟永告[1,2] 谢海涛[3] 彭辉[4] 王振宁[1,2] 魏大年[1,2] 张湘衡[1,2] 赛克[1,2] 邓星海[1,2] 张冠华[1,2] 陈忠平[1,2] 

机构地区：[1]中山大学肿瘤防治中心神经外科,广东广州510089 [2]中山大学肿瘤防治中心华南肿瘤学重点实验室,广东广州510060 [3]广东省中医院神经外科,广东广州510405 [4]中山大学中山医学院免疫学教研室,广东广州510089

出　　处：《中国病理生理杂志》2010年第12期2342-2346,共5页Chinese Journal of Pathophysiology

基　　金：广东省科技计划资助项目(No.20061040645);广州市科技计划资助项目(No.2007Z3-E4061);广东省自然科学基金资助项目(No.8151008901000012);国家自然科学基金资助项目(No.30973080)

摘　　要：目的:探讨共刺激分子4-1BBL(CD137L)在胶质瘤组织中的表达及其临床意义。方法:免疫组化方法检测4-1BBL在82例脑胶质瘤组织中的表达,并分析其与病理分级、患者年龄、性别及生存时间的关系。结果:正常3例脑组织标本未见4-1BBL表达。82例胶质瘤标本31例4-1BBL阳性,阳性表达率为37.8%。统计学提示组织标本中4-1BBL表达与病理级别无明显相关性,与年龄有关(P<0.05),4-1BBL阳性患者生存期更长(P<0.05)。结论:4-1BBL在部分胶质瘤组织中有表达,其表达对判断胶质瘤患者的预后有一定的参考价值。AIM：To investigate the expression of 4-1BBL（CD137L） protein in human glioma tissues,and to analyze its clinical significance.METHODS： The expression levels of 4-1BBL protein in 82 human glioma specimens were measured by the method of immunohistochemistry.The correlation of 4-1BBL protein level with histopathologic features and survival time was analyzed.RESULTS： 4-1BBL protein positive cells were observed in human brain astrocytic tumors,which were not found in meningioma and normal brain tissues.In our study,the expression of 4-1BBL protein in 3 cases of normal brain tissues was negative.The expression of 4-1BBL protein in 31 cases of glioma specimens were positive,and total positive rate was 37.8%（31/82）.The expression of 4-1BBL protein was related to the survival time and age of the patients,but not related to the pathological grade of glioma.Statistically,the patients with positive expression of 4-1BBL protein had longer survival time（P0.05）.CONCLUSION： Expression of 4-1BBL protein may have reference value to predict the prognosis of patients with glioma.

关 键 词：4-1BB配体 神经胶质瘤 预后 

分 类 号：R739.41[医药卫生—肿瘤]