乳腺癌组织中第Ⅷ因子相关抗原和组织蛋白酶D与癌转移及预后的关系  

Factor 8 Related Antigen and Cathepsin D in Human Breast Cancer

作　　者：陶小钰[1] 顾学文[1] 崔飞[1] 

机构地区：[1]江苏省苏北人民医院病理科

出　　处：《南京医科大学学报（自然科学版）》1999年第4期312-314,共3页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的探讨乳腺癌组织中第Ⅷ因子相关抗原和组织蛋白酶Ｄ在其转移、预后中的关系。方法采用免疫组化ＳＰ法对３３例乳腺癌进行第Ⅷ因子相关抗原（Ｆ８）和组织蛋白酶Ｄ（Ｃａｔｈ－Ｄ）染色。结果３３例乳腺癌微血管Ｆ８染色均阳性（１００％）。癌组织内染色阳性在７０％以上者７例（２１．２１％），癌周组织阳性在７０％以上者２５例（７１．６７％），两者有明显差异（Ｐ＜０．０１）。Ｆ８表达与腋窝淋巴结转移有相关性（Ｐ＜０．０１）。３３例乳腺癌Ｃａｔｈ－Ｄ阳性者３０例，占９０．０９％。结论Ｆ８、Ｃａｔｈ－Ｄ免疫组化染色对判断乳腺癌转移、预后有着重要意义。两项同时检测可起互补作用。Objective To study the relationship of Cath c and F8 in cancerous tissue of the breast versus metastasis and prognosis. Methods\ Using immunohistochemistry s p methods, F8 and Cath D in 33 cases of breast cancers were examined. Results\ F8 was positive 100% in 33 cases of breast cancer′s capillary. Positive rate of F8 in breast cancer tissue and surrounding tissue is respectively 21.21% and 71.67%. There is correlation in expression of F8 and axilliary lymph node metastasis ( P <0.01). Cath D positive rate in 33 cases of cancer is 90.09%. Conclusion\ The expression of F8 and Cath D does play an important role in detecting metastasis and prognosis of breast cancer.

关 键 词：乳腺癌 F8 相关抗原 组织蛋白酶D 肿瘤转移 

分 类 号：R737.9[医药卫生—肿瘤] R73-37[医药卫生—临床医学]