唑来膦酸联合化疗治疗31例肿瘤骨转移性疼痛  

Clinical observation of combined zoledronic acid with chemotherapy in 31 cases with pain due to bone metastasis

作　　者：唐文军[1] 朱益平[2] 吴跃文[2] 周静萍[1] 

机构地区：[1]皖南医学院口腔内科学教研室,安徽芜湖241001 [2]皖南医学院附属弋矶山医院肿瘤内科,安徽芜湖241001

出　　处：《皖南医学院学报》2010年第6期417-419,共3页Journal of Wannan Medical College

摘　　要：目的:观察唑来膦酸联合化疗治疗肿瘤骨转移性疼痛的近期疗效及安全性。方法:对治疗组31例骨转移疼痛患者每次给予唑来膦酸注射液4mg加入生理盐水溶液100ml静脉滴注不少于15min,同时联合化疗;对照组29例骨转移疼痛患者单用化疗。3～4周为1周期;连续用药两个周期后评价疗效和不良反应。结果:治疗组疼痛缓解的有效率为70.97%,对照组为44.83%,两组不良反应未见明显差异。结论:化疗联合唑来膦酸治疗晚期肿瘤的转移性骨痛明显优于单纯化疗。Objective：To observe the short-term effect and safety of combined zoledronic acid with chemotherapy in treatment of cancer patients with pain resulted from bone metastasis.Methods：In a treatment circle of 3 to 4 weeks,the treatment group（n=13）received intravenous infusion of zoledronic acid at a dose of 4 mg in saline solution of 100 ml for more than 15 min besides simultaneous chemotherapy,and the control subjects（n=29）were given simple chemotherapy.The efficacy and adverse effect were evaluated after two successive circles of therapy.Results：Pain relief was found in 70.97% of the patients in the treatment group and 44.83% in the controls,though there was no significant difference regarding the adverse effects between the two groups.Conclusion：Chemotherapy in combination with zoledronic acid appears more effective than simple chemotherapy in releasing the pain for the advance cancer patients with bone metastasis.

关 键 词：肿瘤 骨转移 唑来膦酸 

分 类 号：R738.1[医药卫生—肿瘤]