度洛西汀与帕罗西汀治疗老年抑郁症的对照研究  

Comparative study of Duloxetine and Paroxetine in the treatment of senile depression

作　　者：罗瑜[1] 刘雨生[1] 

机构地区：[1]无锡市精神卫生中心,江苏无锡214151

出　　处：《中国民康医学》2010年第24期3123-3123,3141,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:比较度洛西汀与帕罗西汀治疗老年抑郁症的临床疗效和安全性。方法:将59例老年抑郁症患者随机分为度洛西汀组及帕罗西汀组,治疗6周。用汉密尔顿抑郁量表(HAMD)、不良反应量表(TESS)在治疗前及治疗1、2、4、6周末评定临床疗效和不良反应。结果:度洛西汀与帕罗西汀均能明显改善老年抑郁症状,两组显效率分别为80.0%、75.9%,疗效差异无统计学意义(P>0.05),两组不良反应比较无显著性差异(P>0.05),度洛西汀抗抑郁作用于治疗第1、2周开始显现,出现较早。结论:度洛西汀是快速、安全、有效的抗抑郁药之一,可用于治疗老年抑郁症患者。Objective：To compare the eficacy and safety of Duloxetine and Paroxetine in the treatment of senile depression.Methods：60 patients with senile depression were randomly divided into the treatment groups of Duloxetine or Paroxetine for 6 weeks.Hamilton depression scale（HAMD）and treatment emergent symptom scale（TESS）were used to evaluate their clinical eficacy and safety,before treatment and 1,2,4,6 week after treatment.Results：Both Duloxetine and Paroxetine can improve the depressive symptoms of the paitients with senile depression,There were no significant differences in the eficacy and adverse events between the two groups.However Duloxetine took effect more quickly.Conclusion：Duloxetine is a rapid effective and safe antidepressant in the treatment of senile depression,it can be used in senile depression.

关 键 词：度洛西汀 帕罗西汀 老年抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]