胍丁胺抗阿片依赖研究进展  

Progress in agmatine inhibiting opioid dependence

作　　者：李锦[1] 吴宁[1] 李斐[1] 苏瑞斌[1] 

机构地区：[1]军事医学科学院毒物药物研究所一室,北京100850

出　　处：《国际药学研究杂志》2010年第6期401-407,共7页Journal of International Pharmaceutical Research

基　　金：国家重点基础研究发展计划(973计划)资助项目(2009CB522008);国家科技支撑计划(2007BAI07B02)资助项目;国家自然科学基金重点项目(30930040)

摘　　要：阿片成瘾,又称为阿片依赖,是一种慢性复发性脑疾病,可引起一系列严重的社会、经济和公共卫生问题。由于阿片依赖的神经生物学机制尚未阐明,目前仍缺乏有效的医学干预手段。研究阿片依赖的神经生物学机制、寻找有效的防复吸药物已成为阿片依赖研究领域的热点。胍丁胺是一种新发现的候选神经递质或调质,被认为是咪唑啉受体的内源性配体,本文主要以我们的研究工作为基础,对外源性胍丁胺的抗阿片依赖作用特点及其可能的作用机制加以综述。Opioid addiction,also termed opioid dependence,is a chronic, relapsing disorder in brain,which induces a series of severe problems in the aspects of society,economy and public health. Because the neurobiological mechanisms of opioid dependence haven′t been clarified,it lacks effective medical interventions. Researches on opioid dependence are focusing on clarifying its neurobiological mechanisms and discovering effective anti-relapse drugs. Agmatine is a candidate for neurotransmitter or neuromodulator,and considered as an endogenous ligand for imidazoline receptors. Based on our previous work,its pharmacological characteristics and possible mechanisms of agmatine inhibiting opioid dependence were reviewed.

关 键 词：阿片依赖 胍丁胺 咪唑啉受体 

分 类 号：R749.6[医药卫生—神经病学与精神病学]