急性髓系高白细胞白血病患者外周血白细胞介素-1β的表达及意义  

Expression and significance of interleukin-1β in serum of acute myeloid leukemia

作　　者：张秀莲[1] 张伟华[1] 侯素敏[1] 陈玮[1] 陶洁[1] 

机构地区：[1]山西医科大学第一医院血液科,太原030001

出　　处：《白血病．淋巴瘤》2010年第11期663-665,共3页Journal of Leukemia & Lymphoma

基　　金：山西省科技攻关项目（20090311058-5）

摘　　要：目的 检测白细胞介素-1β（IL-1β）在急性髓系白血病（AML）高白细胞患者外周血中的表达,探讨其在细胞淤滞及向组织浸润中的作用.方法 用酶联免疫吸附法（ELISA）测定83例初治AML患者（其中16例为高白细胞白血病患者）血清中IL-1β的含量,比较高白细胞组与非高白细胞组以及浸润组与非浸润组的差别.以40名健康献血员为对照.结果 AML组血清中IL-1β的含量[（88.23±36.30）pg/ml]高于健康对照组[（29.56±15.53）pg/ml],差异有统计学意义（P＜0.01）;AML高白细胞组血清中IL-1β含量显著高于非高白细胞组[（136.67±65.68）pg/ml比（69.85±48.35）pg/ml].IL-1β与外周血白细胞呈直线相关关系（r=0.74,P＜0.01）.浸润组与非浸润组血清中IL-1β水平为：（111.31±57.35）pg/ml比（79.68±43.42）pg/ml,差异有统计学意义.结论 AML患者血清IL-1 β水平与其外周血白细胞数量有关,在一定程度上可反映疾病的病情,可能参与了白血病细胞组织浸润的机制.Objective The interleukin-1β （IL-13） expression in serum of acute myeloid leukemia （AML） patients was evaluated. To explore the significance of IL-1β in leukostasis and tissue infiltration by leukemic cells. Methods ELISA was used to investigate the contents of IL-1β in serum of 83 newly diagnosed with AML which contains 16 hyperleukocytic AML patients, and compared the IL-1β level between the hyperleukocytic AML group and non-hyperleukocytic AML group, the infiltrated group and non-infiltrated group. Results The content of IL-1β in AML serum [（88.23±36.30） pg/ml] was higher than that of in the control group[（29.56±15.53） pg/ml], with significant difference （P 〈0.01）. There was a higher level for IL-1β in hyperleukocytic AML group[（136.67±65.68） pg/ml] than in non-hyperleukocytic AML group [（69.85±48.35） pg/ml],and there was a significant difference. IL-13 and peripheral blood cells were in linear correlation （r=0.74, P 〈0.01）. There was a higher level for IL-1β in infiltrated group[（111.31 ±57.35） pg/ml] than in the other group [（79.68±43.42） pg/ml], and there was a significant difference. Conclusion The IL-1β may play an important role in leukostasis and tissue infiltration by leukemic cells in AML.

关 键 词：白血病 髓样 急性 高白细胞 白细胞介素-1β 白血病浸润 

分 类 号：R733[医药卫生—肿瘤]