E-cadherin表达与喉癌浸润、转移及复发关系的研究  

ECADHERIN EXPRESSION IN LARYNGEAL CANCER:THE RELATIONSHIP WITH TUMOR INVASION,LYMPHATIC METASTASIS AND RECURRENCE

作　　者：郭晓峰[1,2] 李兰 张慰天[1,2] 

机构地区：[1]白求恩医科大学第一临床学院 [2]深圳市儿童医院

出　　处：《山东医大基础医学院学报》1999年第2期67-69,共3页

摘　　要：为研究喉癌细胞浸润及颈淋巴结转移的机制，探讨喉癌转移或复发的早期诊断方法。用免疫组化方法，借助图像分析技术，研究了４０例喉癌Ｅ－ｃａｄｈｅｒｉｎ（Ｅ－ＣＤ）表达与喉癌细胞分化、转移及复发的关系。结果表明：Ｅ－ＣＤ蛋白表达与喉癌细胞的分化程度及浸润性有关。高分化癌细胞具有较强的Ｅ－ＣＤ蛋白表达，低分化癌表达较弱，转移或复发癌缺乏Ｅ－ＣＤ蛋白表达。因此，Ｅ－ＣＤ蛋白表达与喉鳞状细胞癌分化呈正相关，通过对喉原发癌中Ｅ－ＣＤ的检测，可以早期预测喉癌具有浸润。In order to evaluate the role of Ecadherin(ECD)in laryngeal carcinoma cell differentiation,invasion and metastasis,the expression of ECD in human laryngeal squamous cell carcinoma (LC)was studied.40 cases of LC include 33 cases of primary LC, 7 cases of recurrent LC.There were 17 cases of lymph node metastasis.The patients were investigated by immunohistochemistry method with the image pattern analysis.The results showed that the ECD expression were higher in primary cancer than that in metastasis and recurrence tumors.The level was inverse correlated to the cell differentiation.These results suggest that ECD have the suppression role in tumor cell invasion.ECD may be a useful marker in the early diagnosis of tumor metastasis.

关 键 词：钙粘着糖蛋白类 喉肿瘤 肿瘤转移 

分 类 号：R739.650.2[医药卫生—肿瘤]