粘附分子的表达与大肠癌转移相关性的分析  

The level of expression of adhesion molecules CD44v6 and E cadherin in colorectal cancer and analysis of correlates with metastasis

作　　者：顾晋[1] 祝学光[1] 叶颖江[1] 曲军[1] 黄磊 李荣[1] 于永祥[1] 冷希圣[1] 

机构地区：[1]北京医科大学人民医院外科

出　　处：《中华外科杂志》1999年第2期108-109,I004,共3页Chinese Journal of Surgery

基　　金：卫生部中青年科技骨干科研基金

摘　　要：目的检测粘附分子ＣＤ４４ｖ６、Ｅｃａｄｈｅｒｉｎ的表达与人大肠癌转移的关系。方法应用免疫组化方法，测定３２例病理证实的大肠癌标本中ＣＤ４４ｖ６和Ｅｃａｄｈｅｒｉｎ的表达。结果ＣＤ４４ｖ６表达与肿瘤分型、Ｄｕｋｅｓ分期及ＴＮＭ分期无明显相关性，但与淋巴结转移和远处转移明显相关。Ｅｃａｄｈｅｒｉｎ在大多数正常粘膜呈阳性表达，而在大肠癌标本中阳性率仅为４９６％，在有转移的病例中阳性率为２０％。结论ＣＤ４４ｖ６和Ｅｃａｄｈｅｒｉｎ均与大肠癌转移明显相关。Objective To determine the expression of adhesion molceules CD44v6 and E cadherin in colorectal cancer and its relation with metastasis. Methods The expression of CD44v6 and E cadherin in 32 patients with colorectal carcinoma was investigated using immunohistochemical staining,which was performed on surgical specimens. Results No significant correlation with CD44v6 and histologic type, TNM and Dukes staging was noted,but it was significantly correlatied with lymph node and hematogenous metastasis.E cadherin was strongly expressed in normal epithelium examined.However, E cadherin expression in colorectal carcinoma was reduced(positive rate 46 9%).Metastatic colorectal carcinoma showed significant reduction (positive rate 20%). Conclusion CD44v6,E cadherin immunoreativity are significantly correlated with lymph node and hematogenous metastasis.

关 键 词：大肠肿瘤 细胞间粘附分子 肿瘤转移 

分 类 号：R735.340.2[医药卫生—肿瘤] R73－37[医药卫生—临床医学]