阴道内胚窦瘤的诊断和治疗——附二例报告  

Diagnosis and Treatment of Endodermal Sinus Tumor of the Vagina

作　　者：沈铿[1] 黄荣丽[1] 郎景和[1] 崔全材 吴鸣[1] 黄惠芳[1] 连利娟[1] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院妇产科

出　　处：《中华妇产科杂志》1999年第2期105-107,I004,共4页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的探讨阴道内胚窦瘤的临床特点及化疗效果。方法对２例阴道内胚窦瘤进行临床报告及分析。结果阴道内胚窦瘤主要发生在儿童，临床表现主要为阴道出血和息肉状易脆的阴道肿物。血清甲胎蛋白（αＦＰ）水平化疗前均异常升高，病理诊断主要依靠ＳｃｈｉｌｅｒＤｕｒａｌ小体和αＦＰ染色阳性。２例患者分别对顺铂、长春新碱、博莱霉素（ＰＶＢ）方案和顺铂、鬼臼乙叉甙、博莱霉素（ＰＥＢ）方案化疗均有良好反应，２～３个疗程后，患者获得临床完全缓解。结论小儿阴道内胚窦瘤对化疗很敏感，无需再行根治性手术和放疗。血清αＦＰ可作为肿瘤标志物来诊断和监测病情。Objectives To describe the clinical characteristics and the role of chemotherapy in endodermal sinus tumor of the vagina. Method Two patients with endodermal sinus tumor of the vagina were presented focusing on the clinical manifestations and outcome of the chemotherapy. Results Patient′s age was quite young, 2 and 3 years old respectively. Vaginal bleeding and a polypoid and fragile tumor of the vagina were main clinical features. Elevated serum α FP was found before chemotherapy and dropped dramatically to normal if the tumor was sensitive to chemotherapy. Diagnosis was made by pathology and α FP immunohistochemical staining. Both two patient was well responded to cislantin vincristine bleomycin (PVB) and cislantin etoposide bleomycin (PEB) chemotherapy. Clinical and pathological complete remission was obtained after 2～3 courses of chemotherapy without radical surgery and radiotherapy.Conclusions Endodermal sinus tumor of vagina in infant was very sensitive to the chemotherapy. Serum α FP was very useful in diagnosis and monitoring of the disease.

关 键 词：阴道肿瘤 内胚层窦瘤 诊断 治疗 

分 类 号：R737.34[医药卫生—肿瘤]