结肠、直肠癌术前区域动脉灌注化疗的临床病理观察  

Preoperative arterial infusion chemotherapy of colorectal carcinoma pathological and clinical effects

作　　者：顾晋[1] 马朝来[1] 叶颖江[1] 薛卫成[1] 曲军[1] 赵永东[1] 于永祥[1] 冷希圣[1] 祝学光[1] 

机构地区：[1]北京医科大学人民医院外科

出　　处：《中华外科杂志》1999年第6期333-335,I021,共4页Chinese Journal of Surgery

基　　金：卫生部优秀青年科技人才专项科研基金

摘　　要：目的探讨结直肠癌术前区域动脉灌注化疗对临床病理特征的影响及其可行性。方法对３０例结、直肠癌患者以Ｓｅｌｄｉｎｇｅｒ方法插管，行选择性区域动脉造影并行灌注化疗。结果所有病例病理检查均发现沿血管周围的癌细胞发生核固缩、碎裂，胞浆凝固、坏死，细胞间质水肿、纤维增生、炎细胞浸润，血管出现内膜增生、血管炎及血栓形成。结论术前选择性区域动脉灌注化疗可明显改变结直肠癌患者的组织学形态，并使患者临床症状改善，对结直肠癌治疗具有积极的作用。Objective To investigate the pathological and clinical effects of preoperative selective intraCM)arterial infusion chemotherapy on colorectal carcinoma.Methods 30 patients with colorectal carcinoma underwent selective regional arterial angiography by Seldingers method followed by intraarterial infusion chemotherapy. Results changes of karyopyknosis,karyorrhexis,coagulation and necrosis of cytoplasm in cancer cells around vascular vessels were found in all cases.Interstitial edema,invasion of inflammatory cells,fibroelastosis around cancer cells,proliferous intima,thrombus and inflammation of vessels were also found at the same sites.HZConclusions Histological changes are significant after preoperative selective intraarterial infusion chemotherapy for colorectal carcinoma.This therapy can relieve symptoms.

关 键 词：结肠肿瘤 手术前 直肠肿瘤 灌注疗法 

分 类 号：R735.35[医药卫生—肿瘤] R735.37[医药卫生—临床医学]