乳腺原位癌的起源和发展  

The origin and development of breast carcinoma in situ

作　　者：高钟禹[1] 

机构地区：[1]山东省千佛山医院病理科

出　　处：《临床与实验病理学杂志》1999年第2期102-103,I016,共3页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的：探讨乳腺原位癌的起源和发展，兼论乳腺癌组织学分类。方法：观察５０例乳腺原位癌ＨＥ染色切片，部分切片做Ｗｅｉｇｅｒｔ弹力纤维染色及ｖａｎＧｉｅｓｏｎ胶原染色。结果：５０例导管原位癌中３８例（７６％）合并有小叶原位癌；大部分导管原位癌癌巢不是在导管内，而是在小叶的位置，其壁上无弹力纤维包绕。结论：导管原位癌和小叶原位癌均自末梢导管小叶单位发生；小叶原位癌可能是原位癌的早期阶段，可在原位发展为导管原位癌；Purpose To study the origin and development of breast carcinoma in situ, and to evaluate the histological classification of breast cancer. Method The HE stained sections of 50 cases of breast carcinoma in situ were observed. A part of slides was stained with Weigerts method for elastic fibers and vanGiesons technique for collagen. Results (1)38 cases(76%) of lobular carcinoma in situ (LCIS) coexisted in 50 cases of duct carcinoma in situ (DCIS); (2)The most part of DCIS nests was not in the duct, but at the site of the lobules, lacking elastic fibers around them. Conclusion (1)Both duct carcinoma and lobular carcinoma originate from the terminal duct lobular unit; (2)LCIS is the early stage of breast carcinoma in situ and may develop into DCIS at the originating site; (3)The histologic classification of breast carcinoma into duct and lobular type lacks the basis of histogenesis.

关 键 词：组织发生学 病理学 乳腺癌 乳腺原位癌 

分 类 号：R737.9[医药卫生—肿瘤]