几种活性水对大鼠血液流变学的影响  

Effects of activity water on blood rheology in rats

作　　者：张红[1] 陈斌[1] 朱德兵[1] 李红毅[1] 白树民[1] 董海胜[1] 

机构地区：[1]中国航天员科研训练中心,北京100094

出　　处：《食品科技》2010年第12期83-85,共3页Food Science and Technology

基　　金：中国航天医学工程预先研究项目(2007SY5409003)

摘　　要：目的:观察几种活性水对大鼠内毒素引起微循环障碍模型血液流变学与微循环的影响。方法:取健康雄性SPF级Wistar大鼠60只,随机分为对照组、模型组、模型+冰川矿泉水组、模型+频谱水组、模型+电解水组、模型+自行研制活性水组6组,前2组分别自由饮用纯净水,其余各组分别自由饮用各实验水,30 d后对照组腹腔注射注射用水,其余各组均由腹腔注入内毒素5 mg/kg体重造成炎症刺激引起微循环障碍模型后进行实验。造模完成60 min后由心脏取血,采用赛科希德SA-6000全自动血流变仪检测血液流变学指标。结果:大鼠饮用自制水和电解水30 d,血液黏度比模型组低,在低切状态下黏度差别较大,并可显著降低红细胞的聚集程度,对红细胞变形性无明显影响,这与血液黏度的变化一致。结论:自制活性水和电解水能较好地改善由内毒素引起的机体血液黏度、流动性和凝滞性的变化,具有一定的改善大鼠微循环障碍的作用。Objective： To observe the influence of the activity water to the blood rheology of the rat microcirculation disorder model by endotoxin.Methods： Take 60 healthy male SPF rats,divide them into 6 groups of 10 rats.RandomLy appoint them as control group,model group,model plus glacier mineral water group,model plus spectra water group,model plus electrolysis water group,model plus self-made activity water group.They were fed with normal diets which preceding two group drunk the purified water and the post five group drunk the corresponding activity water.After 4 weeks,control group injected aqua pro injectione,other groups injected endotoxin 5 mg/kg by abdominal cavity result in the microcirculation disorder model.With SA-6000 blood rheology full-automatic analysor,draw out the blood of the rats from each group to analyze the various indexes of their blood rheology after model made 60 mins.Results： Compared with the model group,the self-made activity water and spectra water can obviously decrease the low shear viscidity of the whole blood and the aggregation index of the red blood cells（P0.05）,while the deformation index of the red blood cells had no obvious change coinciding with the viscidity of the blood.Conclusion： The self-made activity water and electrolysis water can apparently improve the blood rheology of the microcirculation disorder model caused by endotoxin.

关 键 词：活性水 血液流变性 微循环障碍 

分 类 号：TS201.4[轻工技术与工程—食品科学]