肺腺癌组织中IGF-IR表达与患者临床病理因素及预后的相关性  

Correlations between IGF-IR Expression and Clinicopathological Factors and Prognosis in Patients with Lung Adenocarcinoma

作　　者：张雪艳[1] 冯久贤[2] 沙惠芳[2] 黄进肃[1] 韩宝惠[1] 

机构地区：[1]上海交通大学附属胸科医院肺内科,上海200030 [2]上海交通大学附属胸科医院肺癌研究室,上海200030

出　　处：《中国肺癌杂志》2010年第12期1113-1117,共5页Chinese Journal of Lung Cancer

摘　　要：背景与目的肺腺癌发病率不断升高,而胰岛素样生长因子I受体(insulin-like growth factor I receptor,IGF-IR)是多种生长因子的调控枢纽,在肿瘤细胞的分化、增殖过程中起重要调节作用。本研究旨在为检测肺腺癌组织中IGF-IR表达,并分析其与肺腺癌患者临床病理因素及预后的相关性。方法采用免疫组化方法检测肺腺癌组织IGF-IR表达。卡方检验分析IGF-IR表达与临床病理因素的关系,Kaplan-Meier生存曲线计算生存率,采用Cox分析评估各指标与患者生存期之间的关系。结果 126例肺腺癌组织中,89例可观察到IGF-IR阳性细胞。IGF-IR表达与肺腺癌患者肿块大小及T分期相关,而与年龄、性别、吸烟史、病理分期、分化及CEA等因素及患者的疗效及生存期无明显相关。结论肺腺癌患者表达IGF-IR,与患者的肿块大小和T分期有关,而与预后无关。Background and objective The incidence of lung adenocarcinoma increases rapidly,and IGF-IR is the key mediator of several growth factors signal transduction,therefore it plays an important role in the proliferation and differentiation of cancer cell. The aim of this study is to detect the expression of IGF-IR in lung adenocarcinoma and to evaluate its implication for the clinicopathological factors and prognosis of patients with this disease. Methods The IGF-IR expression was detected by immunohistochemical staining. Correlations between IGF-IR expression with clinicopathological factors were analyzed using the Chi-squared test. The Kaplan-Meier method was used to calculate the overall patient survival rate,and the difference in survival curves was evaluated using a Log-rank test. Univariate and multivariate analysis was carried out using the Cox proportional-hazard model. Results In 126 cases of tumor sections tested,IGF-IR were detected in 89 cases. Statistical analysis revealed that the IGF-IR expression was related to tumor size and T stage,while there were no relations between IGFIR expression and age,gender,smoking,pathological stages,and differentiation. Cox analysis indicated that metastasis and chemotherapy efficacy were the prognostic factors in these patients,while IGF-IR expression was not the independent prognostic factor. Conclusion The IGF-IR expression is related to tumor size and T stage,while there is no relation between IGF-IR expression and prognosis.

关 键 词：肺肿瘤 IGF-IR 预后 

分 类 号：R734.2[医药卫生—肿瘤]