雄激素与缺血性脑血管病  

Androgen and ischemic cerebrovascular disease

作　　者：于海燕[1] 宫殿荣[2] 陈德哲[2] 

机构地区：[1]泰山医学院研究生院, 泰安271000 [2]泰山医学院附属聊城市人民医院神经内科,聊城252000

出　　处：《国际脑血管病杂志》2010年第10期773-776,共4页International Journal of Cerebrovascular Diseases

摘　　要：雄激素具有广泛的生物学效应.雄激素及其受体广泛存在于心脑血管系统,并在缺血性脑血管病（ischemic cerebrovascular disease,ICVD）发生和发展的多个环节发挥着重要的保护作用.除参与调节ICVD发病的危险因素,如动脉粥样硬化、血脂异常、高血压、凝血-纤溶异常、肥胖、糖尿病等外,雄激素还具有神经保护作用.文章对雄激素在ICVD中的保护作用进行了综述.Androgen has broad biological effects. Androgen and its receptor exist widely in the cardio-cerebrovascular system and play an important protective effect in the multiple aspects of the occurrence and development of ischemic cerebrovascular disease （ICVD）. In addition to involving in regulating the risk factors for ICVD, such as atherosclerosis,dyslipidemia, hypertension, coagulation-fibrinolysis abnormalities, obesity, and diabetes, androgen also has neuroprotective effect. This article reviews the protective effect of androgen in ICVD.

关 键 词：雄激素类 受体 雄激素 脑缺血 卒中 危险因素 神经保护药 

分 类 号：R743.3[医药卫生—神经病学与精神病学]