弥散张量成像在评价脑肿瘤瘤周水肿中的应用价值  

Quantitatively peritumoral edema in intracranial tumors by using diffusion tensor imaging

作　　者：孟海霞[1] 马强[1] 刘娜嘉[1] 

机构地区：[1]宁夏医科大学第一附属医院,宁夏银川750004

出　　处：《宁夏医学杂志》2010年第12期1140-1141,F0003,共3页Ningxia Medical Journal

摘　　要：目的评价弥散张量成像(DTI)定量指标平均弥散系数(MD)及各向异性分数(FA)在鉴别瘤周水肿区域性质中的应用价值。方法回顾性分析经手术病理证实的的40例幕上脑肿瘤患者的DTI资料,比较不同肿瘤瘤周水肿区及高级别胶质瘤不同成分间的MD值、FA值。结果高级别胶质瘤与转移瘤比较,MD值、FA值均无统计学意义(P>0.05);转移瘤与脑膜瘤比较,MD值、FA值均有统计学意义(P<0.05);高级别胶质瘤FA值明显低于脑膜瘤(P<0.01),两者MD值比较无统计学意义(P>0.05)。结论瘤周水肿区MD、FA的定量测量结合FA图的形态学改变,有助于鉴别瘤周水肿区域性质,进而界定肿瘤的真实际边界。Objective To evaluate whether DTI metrics of peritumoral edema,including mean diffusion coefficient（MD） and Fractional anisotropy（FA） can be used to differentiate nature of peritumoral edema.Methods Conventional MRI and diffusion-tensor imaging（DTI） were performed preoperatively in 40 patients with intracranial neoplasms in our hospital.MD and FA values of peritumoral edema area in 3 tumor types were measured;both values were also measured in solid portion and peritumoral edema area of high-grade gliomas.Results Peritumoral MD and FA values indicated no statistically significant difference between high-grade gliomas and metastatic tumors（P0.05）,while there was a statistically significant difference between metastatic tumors and meningiomas（P0.05）.The measured peritumoral FA of high-grade gliomas was significantly lower than that of meningiomas（P0.01）,while the MD value of them showed no significant difference（P0.05）.Conclusion Measuring the peritumoral MD and FA and analyzing the characteristics of FA map can be used to differentiate nature of peritumoral edema,and then to fix the exact margin of tumors.

关 键 词：弥散张量成像 瘤周水肿 各向异性分数 平均弥散系数 

分 类 号：R739.4[医药卫生—肿瘤]