高铝暴露癫痫患者前炎症因子水平变化的临床观察  

Clinical study of cell factor change in high alumina exposed epilepsy patients

作　　者：韦世革[1] 李天资[1] 李雪斌[1] 唐雄林[1] 梁烨[1] 

机构地区：[1]右江民族医学院临床学院,广西百色533000

出　　处：《右江医学》2010年第6期662-664,共3页Chinese Youjiang Medical Journal

基　　金：广西自然科学基金资助项目(桂科自0499007)

摘　　要：目的探讨高铝暴露癫痫患者细胞因子水平变化及其与临床发病的关系。方法选取高铝暴露区癫痫大发作患者12例,观察其发作特征,检测其血清铝、血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平,并与13例非高铝暴露区癫痫大发作患者和12例非高铝暴露区健康体检者比较。结果高铝暴露组的癫痫发作频率、发作持续时间、合并新类型率均高于非高铝暴露组(P<0.05或0.01),高铝暴露组脑电图阳性率高于非高铝暴露组,但差异无统计学意义(P>0.05)。高铝暴露组血铝水平显著高于非高铝暴露组和正常对照组(P<0.05或0.01),非高铝暴露组血铝水平高于正常对照组,但差异无统计学意义(P>0.05)。高铝暴露组血清TNF-α、IL-6、IL-8水平高于非高铝暴露组(P<0.01),非高铝暴露组又高于正常对照组(P<0.05)。结论高铝暴露癫痫患者具有血铝水平高,癫痫临床症状重,致炎因子水平高,御炎因子水平低等特点,高铝暴露或血铝增高的癫痫患者其临床症状和细胞因子功能负面变化较血铝正常者大,提示血铝升高可能加重癫痫患者病情。Objective To explore the cell factor change in high alumina exposed epilepsy patients and the relation with clinic occurrence.Methods 12 patients with grand mal epilepsy who lived in high alumina area were chosen as high alumina exposed group,observed their clinical features and detected the blood alumina,serum tumor necrosis factor-α（TNF-α）,interleukin-6（IL-6） and interleukin-8（IL-8） level.So did 13 grand mal epilepsy patients（none-alumina exposed group） and 12 healthy person（control group） live in none-alumina exposed area,then compared the data among groups.Results The seizure frequency,seizure duration and rate of combined new seizure type in the high alumina exposed group was higher than those in the none-alumina exposed group（P〈0.05 or 0.01）.There are no statistical significant difference between the high alumina exposed group and the none-alumina exposed group upon electroencephalogram（EEG）positive rate（P〈0.05）.Blood alumina level in the high alumina exposed group was higher than those in the none-alumina exposed group and control group（P〈0.05 or 0.01）.Blood alumina level of the none-alumina exposed group was higher than that of control group,but there was no statistical significant difference between them（P〈0.05）.The blood TNF-α、IL-6、IL-8 level in the alumina exposed group was higher than the none-alumina exposed group,and the blood TNF-α、IL-6、IL-8 level in the none-alumina exposed group was higher than the control group（P〈0.01）.Conclusion The blood alumina and cell factor level of the high alumina exposed epileptic patients was high,and the epileptic clinical symptom was badly.High alumina exposed or increasing blood alumina level would bring more negative affect to epileptic patients than normal blood alumina level.That promoting epileptic patients health would worsen if exposed to high alumina condition.

关 键 词：癫痫 高铝暴露 TNF-Α IL-6 IL-8 

分 类 号：R742.1[医药卫生—神经病学与精神病学]