颌面部巨细胞纤维母细胞瘤临床病理分析  

Clinicopathologic characteristics of giant cell fibroblastoma

作　　者：曹灵[1,2] 王聪[3] 张纬明[3] 范钦和[3] 

机构地区：[1]南京医科大学口腔医学研究所 [2]南京医科大学附属口腔医院,南京210029 [3]南京医科大学第一附属医院,南京210029

出　　处：《口腔生物医学》2010年第4期194-197,共4页Oral Biomedicine

摘　　要：目的研究颌面部巨细胞纤维母细胞瘤的临床及病理特点,探讨其鉴别诊断及治疗。方法采用苏木素-伊红(HE)染色和免疫组化标记,对2例发生于颌面部的巨细胞纤维母细胞瘤进行分析。结果 2例患者均为男性,患病年龄分别为14岁和2个月。临床表现为皮下缓慢增大的无痛性结节,直径为2.5cm和3cm。镜下肿瘤境界不清,主要位于真皮层,瘤细胞主要由轻至中度异型的梭形细胞组成,特征性形态表现为肿瘤内含有一些不规则分布的裂隙样或窦样扩张的假脉管性腔隙,其腔隙面内衬一层不连续的核深染的梭形或多核巨细胞。免疫组化标记显示梭形细胞和多核巨细胞均表达波形蛋白和CD34。2例随访,其中1例术后18月复发。结论巨细胞纤维母细胞瘤是一种好发于婴幼儿的中间型软组织肿瘤,较易局部复发,局部扩大切除可减低复发可能,掌握其独特的临床病理学特征对避免误诊为一些具有相似形态的病变具有重要意义。Objective To study the clinicopathologic characteristics of giant cell fibroblastoma （GCF）,with emphasis on differential diagnosis and treatment.Methods 2 cases of GCF were investigated by light microscope and immunohistochemistry. Results All patients were males. Age of onset ranged from 2 months to 14 years. Clinically,all case appeared as slowly growing painless subcutaneous nodules with 2.5 cm and 3 cm diameter. Microscopically,the tumors were mainly located in the epidermis layer,the poorly circumscribed tumors were composed of a proliferation of slightly to moderately atypical spindle cells,which were arranged in parallel or wary fascicle. The pathognomonic feature consisted of irregular distributed cleft-like or sinusoid-like pseudovascular spaces lined with a discontinuous layer of pleomorphic spindle cells and multinucleate giant cells. Immunohistochemically,both the spindle cells and multinucleate giant cells expressed vimentin and CD34. Follow-up information：1 case of recurrence 18 months after surgery. Conclusions GCF is a interphyletic soft tissue tumors of childhood,easier for local recurrence,and with the characteristic features of GCF is helpful at diagnosis and differential diagnosis.Extended resection may reduce recurrence of tumor.

关 键 词：颌面部 巨细胞纤维母细胞瘤 临床 病理 

分 类 号：R739.81[医药卫生—肿瘤]