乳腺癌患者血清VEGF、IGF-Ⅰ水平的变化及临床意义  

Clinical Significance of Changes of Serum VEGF,IGF-Ⅰ Levels in Patients with Breast Cancer

作　　者：张云燕[1] 

机构地区：[1]江苏省连云港市第一人民医院检验科,222002

出　　处：《放射免疫学杂志》2010年第6期679-680,共2页Journal of Radioimmanology

摘　　要：目的:探讨乳腺癌患者血清血管内皮生长因子(VEGF)、胰岛素样生长因子-Ⅰ(IGF-Ⅰ)水平的变化及其临床意义。方法:采用酶联免疫吸附试验测定49例乳腺癌、30例乳腺良性病变患者的VEGF、IGF-Ⅰ的水平,并以35例正常人为对照。结果:乳腺癌患者血清VEGF、IGF-Ⅰ水平明显高于乳腺良性肿瘤患者及正常人对照组,差异有显著意义(P<0.01)。有淋巴结转移的患者VEGF、IGF-Ⅰ水平明显高于无淋巴结转移的患者,有明显差异(P<0.01)。结论:乳腺癌患者血清VEGF、IGF-Ⅰ水平变化可能成为鉴别乳腺良恶性病变的辅助指标之一,有助于判断有无淋巴结转移及预后。Objective To study the clinical significance of changes of serum VEGF, IGF-Ⅰ levels in patients with breast cancer. Methods Serum VEGF, IGF-Ⅰ levels were detected with ELISA in 49 patients with breast cancer, 30 patients with benign breast diseases and 35 controls. Results Serum VEGF, IGF-Ⅰ levels were significantly higher in the patients than those in patients with benign breast diseases and controls （P〈0.01）. Among the patients with breast cancer, the serum levels of VEGF and IGF-Ⅰ in the 14 patients with lymph nodes metastatic were significantly higher than those in the 35 patients without lymph nodes metastatic （P〈0.01）. Conclusion Detection of changes of serum VEGF, IGF-Ⅰ levels was helpful to the differential diagnosis of malignant from benign diseases, also helpful for lymph nodes metastatic prediction.

关 键 词：乳腺癌 血管内皮生长因子 胰岛素样生长因子-Ⅰ 

分 类 号：R734.205[医药卫生—肿瘤]