盐酸多奈哌齐治疗老年人认知功能障碍疗效及安全性观察  

Safety and efficacy of donepezil in elderly patients with cognitive impairment

作　　者：汪海娅[1] 王传馥[2] 赵咏桔[3] 盛净[4] 朱福[5] 张华[6] 倪秀石[7] 江蓓湖[8] 冯曹波[9] 钟远[10] 张淑华[11] 梅柳松[12] 魏文石[2] 方宁远[1] 

机构地区：[1]上海交通大学医学院附属仁济医院老年病科,上海市200001 [2]复旦大学附属华东医院,上海市200040 [3]上海交通大学医学院附属瑞金医院老年病科,上海市200025 [4]上海交通大学医学院附属第九人民医院,上海市200011 [5]上海市徐汇区中心医院,上海市200031 [6]上海同济大学附属东方医院,上海市200120 [7]上海交通大学医学院附属上海市第一人民医院,上海市201620 [8]上海中医药大学附属普陀医院,上海市200062 [9]第二军医大学长海医院,上海市200433 [10]上海交通大学附属第六人民医院,上海市200233 [11]上海同济大学附属第十人民医院,上海市200072 [12]上海中医药大学附属曙光医院,上海市200021

出　　处：《老年医学与保健》2010年第6期351-353,共3页Geriatrics & Health Care

摘　　要：目的观察盐酸多奈哌齐（Donepezil）治疗老年人认知功能障碍的有效性及安全性。方法对517例老年认知功能障碍患者行盐酸多奈哌齐治疗，观察6m。应用简易精神状态检查（MMSE）评定临床疗效，并记录治疗过程中的副反应。结果盐酸多奈哌齐在治疗3m起MMSE评分显著升高，第6月有继续上升趋势（P〈0．05），治疗总有效率为65％。盐酸多奈哌齐对中、重度认知功能障碍者作用显著，入选时MMSE评分与MMSE改善程度呈负相关。盐酸多奈哌齐治疗不良反应轻微，仅有2例患者存在轻度的恶心或胃纳减退，无严重不良反应。结论盐酸多奈哌齐能有效治疗老年认知功能障碍，病情较重的患者MMSE改善更明显；药物治疗不良反应少而轻微。Objective To investigate the therapeutic effects of donepezil on the cognitive impairment in elderly patients. Method 517 elderly patients with cognitve impairment were enrolled in our study. Patients were treated with donepezil for 6 months. The clinical outcome of donepezil for the patients Was assessed with Mini Mental State Examination （MMSE） before and after the treatment. Results MMSE scores were significantly improved after donepezil treatmerit （P〈0.05） , and the effective rate was 65 %. Donepezil was more effective in patients with moderate to severe cognitive impairment. The most common adverse events were nausea and loss of appetite （0.4 %）, and no sever adverse effect were found during the treatment. Conclusion Donepezil can significantly improve the cognitive impairment in elderly patients.

关 键 词：老年 认知功能障碍 盐酸多奈哌齐 

分 类 号：R741[医药卫生—神经病学与精神病学]