晚期舌癌舌动脉栓塞化疗的微血管变化  

Changes of microvessels by arteria lingualis chemoembolization to advanced stage carcinoma of tongue

作　　者：梁军[1] 游云华[1] 林宇静[2] 张华伟[1] 刘本艳[1] 

机构地区：[1]中山大学附属第五医院口腔颌面外科,广东珠海519000 [2]中山大学附属第五医院病理科,广东珠海519000

出　　处：《中华临床医师杂志（电子版）》2010年第10期38-40,共3页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的分析晚期舌癌行舌动脉超选择栓塞化疗的微血管变化。方法应用SP免疫组织化学方法,检测17例晚期舌癌患者手术后病理标本的微血管变化,其中7例接受舌动脉超选择栓塞化疗后手术,10例接受静脉化疗后手术。结果舌动脉栓塞化疗组微血管计数比静脉化疗组减少,组间差异具有统计学意义(P<0.01);舌动脉栓塞化疗组的微血管形态多表现为窦状扩张型,静脉化疗组的微血管形态以芽状和条索状为主;动脉栓塞前后舌动脉及分支的显影对比,栓塞后舌动脉及分支变细,舌动脉远端及细小分支不显影。结论观察晚期舌癌术前栓塞化疗的微血管变化,对临床肿瘤的治疗和预后评估有一定作用,可作为术前的一项常规治疗。Objective To analyze changes of microvessels by arteria lingualis chemoembolization in target to advanced stage carcinoma of tongue.Methods SP immunochemistry was applied to detect changes of microvessels in 17 cases of advanced stage carcinoma of tongue after operations,including 7 cases by arteria lingualis chemoembolization and 10 cases by vein chems.Results The microvessels quantity of arteria lingualis chemoembolization group were less than those of vein chems group,there was significant difference between the two groups（P〈0.01）;microvessels morphous of arteria lingualis chemoembolization group were expansive blood sinus,that of vein chems group were slim bud and trabs;in contrast to lingual artery and branch developing before and after arterial embolism,lingual artery and branch became tiny,distal end lingual artery and small branch were nonvisulization.Conclusions Observation on changes of microvessels by chemoembolization to advanced stage carcinoma of tongue contribute to therapy and prognosis evaluation of tumour,it can be a conventional therapy.

关 键 词：舌肿瘤 化学栓塞 治疗性 毛细血管 

分 类 号：R739.86[医药卫生—肿瘤]