复方苦参注射液联合TP方案治疗晚期NSCLC临床观察  

Clinical Effects of TP Project Combined with Compound Matrine Injections on Advanced Non-Small-Cell Lung Cancer

作　　者：庞东生[1] 许扬[1] 汪雪原[1] 宋志刚[1] 

机构地区：[1]海军安庆医院肿瘤内科,安徽省安庆市246003

出　　处：《中华全科医学》2011年第1期50-50,164,共2页Chinese Journal of General Practice

摘　　要：目的观察复方苦参注射液联合化疗治疗晚期非小细胞肺癌的疗效与不良反应。方法 62例晚期非小细胞肺癌的患者,随机分为对照组30例:紫杉醇135 mg/m2,d1,静滴;顺铂30 mg/m2,d1～3静滴(TP方案)和治疗组32例:复方苦参注射液联合TP方案,两组病例的临床资料具有可比性。两组患者的治疗,均每21 d为1个治疗周期,3个周期为一疗程。结果两组患者中,治疗组在近期疗效、卡氏评分、控制疼痛及不良反应等方面都优于对照组,P<0.05。结论 TP方案联合中药复方苦参注射液治疗非小细胞肺癌具有较好的耐受性和安全性,近期疗效等优于对照组。Objective To observe the effect of compound matrine injections combined with chemotherapy on advanced nonsmall cell lung cancer（NSCLC） and its side effects. Methods Sixty two patients with advanced NSCLC were randomly divided into two groups ： the control group （ 30 cases ） received TP regimen （ paclitaxel 135 mg/m^2, d1, intravenous ; cisplatin 30 mg/m^2, d1-3 infusion） ;the experiment group （32 cases） received the combination therapy with compound matrine injections and TP regimen. The clinical data of two groups were comparable. A treatment cycle was 21 days,and 1 course included 3 cycles in both groups. Results The short term effect, Karnofsky score, pain control and adverse effects in the treatment group were all superior to that in the control group （P 〈 0.05）. Conclusion TP regimen combined with traditional Chinese medicine compound matrine injections shows a good tolerance and safety in treating advanced NSCLC ,and the short term effect is better than single TP regimen.

关 键 词：晚期非小细胞肺癌 复方苦参注射液 化疗 

分 类 号：R734.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]