中医“肺应秋”调控机制与褪黑素受体关系的研究  

Research on relationship between control mechanisms of TCM 'the lung corresponding with autumn' and the melatonin receptors

作　　者：马淑然[1] 赵树宏[1] 肖延龄 李彦军[3] 袁卫玲[1] 苏薇[1] 刘燕池[1] 

机构地区：[1]北京中医药大学,北京100029 [2]北京同仁堂中医医院,北京100040 [3]中国藏学研究中心北京藏医院,北京100029

出　　处：《中华中医药杂志》2011年第1期65-68,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：教育部科学技术重大研究项目(No.105030);国家自然科学基金(No.30672567)~~

摘　　要：目的:通过观察肺组织褪黑素受体的季节性变化,深入揭示"肺应秋"的调控机制。方法:采用ELISA法,检测雄性Wistar大鼠肺组织褪黑素受体春分、秋分、夏至、冬至季节性变化。结果:①大鼠肺组织褪黑素受体含量四季生理组春分、冬至与秋分比较,均有显著差异(P<0.05);②手术组(松果腺摘除模型组)夏至与春分比较,有显著性差异(P<0.05),冬至与春分比较,有极显著性差异(P<0.01);③四季伪手术组春分、秋分、冬至与夏至比较,均有极显著差异(P<0.01),秋分、冬至与春分比较,均有非常显著差异(P<0.01);④同一季节3组之间比较,秋分时,手术组褪黑素受体含量明显高于生理组,有显著性差异(P<0.05),生理组与伪手术组比较,差异不显著。结论:"肺应秋"免疫调控机制与肺组织褪黑素受体的季节性变化有关,松果腺在"肺应秋"免疫调控过程中起着重要的高位调节作用。Objective： To observe the lung tissue of the seasonal changes of melatonin receptors,in-depth reveal ＇the lung corresponding with autumn＇ the regulation mechanism.Methods： The ELISA method to detect male wister melatonin receptor in rat lung tissue from two points two seasonal variations.Results： ① melatonin receptor in rat lung tissue content of the four seasons physiological group Equinox,Winter Solstice and the Autumnal Equinox comparison,were significantly different（P0.05）;②operation（removal of the pineal gland model group） Comparison of the summer solstice and the vernal equinox there was significant difference（P0.05）,the winter solstice and the vernal equinox of comparison,there was a significant difference（P0.01）;③ Four Seasons pseudo-operation group,Equinox,Autumnal Equinox,Winter Solstice and Summer Solstice comparison,there was significant difference（P0.01）,Autumnal Equinox,Winter Solstice and Vernal Equinox of comparison,there was a significant difference（P0.01）;④ comparison between the three groups the same season,Autumnal Equinox,the surgical group were significantly higher than the physiological melatonin receptor group.There was a significant difference（P0.05）,physical group and the sham-operated group,no significant difference（P0.05）.Conclusion： ＇The lung corresponding with autumn＇ immune regulation mechanism of melatonin receptor in lung tissue of seasonal changes,the pineal gland in the ＇Lung corresponding with autumn＇ the process of immune regulation plays an important high regulatory role.

关 键 词：肺应秋 肺组织 褪黑素受体 WISTAR大鼠 

分 类 号：R223.11[医药卫生—中医基础理论]