survivin和PTEN在非小细胞肺癌中的表达及其意义  

Expressions and Significance of Survivin and PTEN in Non-small Cell Lung

作　　者：姚文健[1] 白玉[2] 赵国昌[1] 王永连[1] 王忠民[1] 

机构地区：[1]河南省新乡医学院第一附属医院胸外科,河南卫辉453100 [2]河南省新乡医学院病理教研室,河南卫辉453003

出　　处：《中国医药指南》2011年第2期36-36,51,共2页Guide of China Medicine

摘　　要：目的探讨凋亡抑制基因survivin和抑癌基因PTEN在非小细胞肺癌(NSCLC)中的表达及临床意义。方法应用免疫组织化学SP法检测120例NSCLC组织、20例正常肺组织中survivin及PTEN的表达情况,结合临床资料进行分析。结果 survivin随着肿瘤恶性程度增高,阳性表达率逐渐升高,而PTEN的表达则相反,二者在肿瘤中的表达呈负相关(r=-0.235,P<0.01)。结论 survivin和PTEN的异常表达与NSCLC的发生发展有关,可作为非小细胞肺癌预后的参考指标。Objective To investigate the expression of survivin and PTEN in non-small cell lung carcinoma（NSCLC） and its clinical significance.Methods The expressions of survivin and PTEN were determined by immunohistochemical technique（SP）in 120cases of NSCLC tissue and 20 cases of normal lung tissue.The results were analyzed in relation to the clinical data.Results The expression of survivin increased gradually as increasing of malignancy.The expression of PTEN appeared in a reverse way.Their expression had a negative correlation between each other（r=-0.235,P0.01）.Conclusions The abnormal expression of survivin and PTEN gene may promote tumor genesis and progression of NSCLC and can be used as the marker of patient＇s prognosis.

关 键 词：suirvivin PTEN 非小细胞肺癌 免疫组织化学 预后 

分 类 号：R734.2[医药卫生—肿瘤]