熔融法制备碘化钾蜡质骨架缓释片的工艺影响因素考察  

Investigation on the influence-factor of preparation of potassium iodine wax matrix sustained-release tablets by melting method

作　　者：方平飞[1] 刘晓磊[2] 赵绪元[1] 李焕德[1] 蒋云生[1] 

机构地区：[1]中南大学湘雅二医院,湖南长沙410011 [2]中南大学药学院,湖南长沙410011

出　　处：《中国医院药学杂志》2011年第1期35-38,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:系统性考察和优化碘化钾蜡质骨架缓释片的制备工艺。方法:通过单因素考察确定主要影响因素,再进行正交设计优化确定较佳的制备工艺。结果:熔融法制备碘化钾蜡质骨架缓释片最优工艺条件为:加热温度90℃、冷却速度20min,压片时间为制粒后48h。结论:筛选优化的制备工艺稳定可控,重复性好。OBJECTIVE To systematically investigate and optimize the preparation technique of potassium iodine wax matrix sustained-release tablets. METHODS Determined the main influencing factors by using single-factor test, and then optimized the preparation technique by orthogonal experiments, RESULTS The final optimized technological conditions were as follows： heating temperature：90 ℃ cooling speed：20 mira compressing time., within 48 hours after granulation. CONCLUSION The selected preparation technique is stable and controllable,it is proved to have a good manufacturing reproducibility.

关 键 词：熔融法 制备工艺 蜡质 缓释片 

分 类 号：R943[医药卫生—药剂学]