联合检测血清四种肿瘤标志物对肺癌的诊断价值  

Diagnostic value of combined detection of four serum tumor markers in patients with lung cancer

作　　者：邵良荣[1] 邵杰[2] 肖丽华[1] 季建伟[1] 

机构地区：[1]东南大学医学院附属盐城医院,江苏盐城224001 [2]南京中医药大学第一临床医学院

出　　处：《中国实用医刊》2011年第1期22-24,共3页Chinese Journal of Practical Medicine

摘　　要：目的评价组织多肽特异性抗原（TPS）、癌胚抗原（CEA）、神经元特异性烯醇化酶（NSE）、细胞角蛋白21—1（CYFRA21-1）联合检测对肺癌的诊断价值。方法应用电化学发光法（ECLIA）检测经病理确诊的83例肺癌、41例良性肺部疾病和30例正常体检者血清中CEA、NSE、CYFRA21—1和TPS的含量。结果肺癌组TPS、CEA、NSE、CYFRA21—1测定水平明显高于肺良性病变组和正常对照组，差异有统计学意义（P〈0．05或P〈0．01）；TPS、CEA、NSE、CYFRA21—1对肺癌的敏感性分别为84．34％、51．81％、43．37％、66．26％，特异性分别为81．93％、79．52％、77．11％、80．72％，诊断符合率分别为83．13％、68．67％、69．88％、79．95％；TPS、CEA、NSE、CY—FRA21—1四项联合检测对肺癌的敏感性、特异性和诊断符合率分别为92．77％、93．97％和95．18％。结论TPS、CEA、NSE、CYFRA21—1四项肿瘤标记物联合检测可提高肺癌检测的敏感性、特异性和准确性。Objective To estimate the diagnostic value of combined detection of TPS, CEA, NSE,CYFRA21 - 1 in patients with lung cancer. Methods The content of serum CEA, NSE, CY- FRA21 - 1 and TPS were detected with ECLIA. There were three groups ： eighty - three pathologically confirmed cases of lung cancer in lung cancer group, 41 benign pulmonary, disease cases in benign pul- monary disease group and 30 normal volunteers in normal healthy group. Results The levels of serum TPS, CEA, NSE, CYFRA21 - 1 in lung cancer group were significantly higher than that in benign pul- monary disease group and normal healthy group, with a statistically significant decrease （ P 〈 0.05 or P 〈 0.01 ）. The sensitivity of TPS, CEA, NSE, CYFRA21 - 1 to lung cancer was 84. 34% , 51.81% , 43.37% and 66.26% , respectively ; the specificity was 81.93% , 79.52% , 77.11% and 80. 72% , re- spectively, and the coincidental rate of the diagnosis was 83.13% , 68.67% , 69.88% and 79.95%, re- spectively. While the sensitivity, specificity and the coincidental rate of the diagnosis to lung cancer was 92.77% ,93.97% and 95. 18%, respectively, with combined detection of four serum tumor markers （TPS, CEA, NSE, CYFRA21 - 1 ） in lung cancer patients. Conclusions The combined detection of the four serum tumor markers（TPS, CEA, NSE, CYFRA21 -1） can improve the sensitivity, specificity and accuracy in lung cancer detection.

关 键 词：组织多肽特异性抗原 神经元特异性烯醇化酶 癌胚抗原 细胞角蛋白21—1 肺癌 肿瘤标志物 

分 类 号：R734.2[医药卫生—肿瘤]