Effect of three suture lines on the proliferation and cell cycle of lung adenocarcinoma cell A549 in vitro  

三种缝线材料对人肺腺癌细胞A549增殖和细胞周期的影响(英文)

作　　者：Lianhua Ye,Yunchao Huang,Qilin Jin,Feng Hua,Guangqiang Zhao Department of Thoracic Surgery,Third Affiliated Hospital,The Kunming Medical College Tumor Hospital of Yunnan Province,Kunming 650118,China 

出　　处：《The Chinese-German Journal of Clinical Oncology》2011年第1期15-18,共4页中德临床肿瘤学杂志（英文版）

基　　金：Supported by the grants from the National Natural Science Foundation of China (No.30872555, 81000672);Yunnan Provincial Science Foundation (No.2008ZC139M, 2009CD184);the High-level Personal Fund of Yunnan Province Introduction (No.20080C014)

摘　　要：Objective： The interaction of cell and medical biomaterial is one of the significant factors to affect clinical application of medical biomaterial. This research is to investigate three of suture lines how to affect the proliferation and cell cycle of lung adenocarcinoma cell A549 in vitro. Methods： Three of suture lines were respectively cultivated with lung adenocarcinoma cell A549, after of 72 hours, we detected absorptions of each group by MTT method in order to reflect the proliferation of lung adenocarcinoma cell A549, and also examined percentage of G1 period cells and S period cells of each group by flow cytometry. Results： Different of suture lines had different effects on the proliferation and cell cycle of lung adenocarcinoma cell A549 （P 〈 0.05）. The effect of absorbent suture line was the strongest on the proliferation and cell cycle of lung arlenecarcinoma cell A549, the effect of chorda serica chirurgicalis was medium, and the effect of slide wire was poor. Different length of each suture line had different effects on the proliferation and cell cycle of lung adenocarcinoma cell A549 （P 〈 0.05）, Conclusion： Three of suture line materials have different effects on the proliferation and cell cycle of lung adenocarcinoma cell A549, with dose-effect relationship.

关 键 词：suture line lung adenocarcinoma cell multiplication cell cycle 

分 类 号：R734.2[医药卫生—肿瘤]