胸腺发育与衰老相关基因调控的研究进展  

Research progress of gene regulation in thymus development

作　　者：郭智彬[1] 朱喜科[1] 

机构地区：[1]中国医科大学附属盛京医院实验研究中心,辽宁110004

出　　处：《国际免疫学杂志》2011年第1期24-27,共4页International Journal of Immunology

基　　金：国家自然基金资助项目（编号30872715）;辽宁省自然科学基金项目（编号20082082）

摘　　要：胸腺是人体内重要的中枢免疫器官，是T淋巴细胞成熟的场所。在骨髓中产生的淋巴造血祖细胞通过血液进入胸腺，与胸腺基质细胞相互作用，最终形成成熟的CD4^＋／CD8^＋T细胞，返回到血液中参与细胞免疫。现在已发现许多基因参与胸腺发育、衰老，如Foxn1、Hox、Writ4等。这些基因在胸腺组织内形成一个网络，相互制约影响，调控着胸腺的发育及衰老。到目前为止，发育衰老的机制还不完全清楚，其在胸腺发育衰老过程中扮演着重要角色，因而研究胸腺发育衰老过程相关基因的调控机制非常必要。Thymus is a centrol immune organ in human body, and a place where T lymphocytes mature. Lymphoid progenitor cells which are generated in the bone marrow enter the thymus through the blood, and interact with thymic stromal cells, and develop to CIM ＋/CD8 ＋ T cells. The mature T cells return to the blood and finally play role in cell immunity. Many genes are involved in thymus development and aging, for example Foxnl, Hox, Wnt4, etc. These genes form a network of mutual restraint effect in the thymic tissue, which regu- lates the growth and aging of thymus. Recent studies show that miRNA also plays an important role in these e- vents. The mechanism of thymic development and aging is still not clear. This article summaries the recent pro- gress on the mechanisms of gene regulation during the thymic development and aging.

关 键 词：胸腺 器官发育 基因调控 增龄性胸腺萎缩 

分 类 号：R3[医药卫生—基础医学]