树突状细胞疫苗在妇科肿瘤免疫治疗中的研究进展  

Progress on the study of dendritic cells vaccine in immunotherapy for gynecological cancer

作　　者：宣恒华[1] 赵卫东[1] 

机构地区：[1]安徽医科大学附属省立医院妇产科,合肥230001

出　　处：《国际免疫学杂志》2011年第1期32-35,共4页International Journal of Immunology

基　　金：2008年安徽省科技攻关计划项目（08010302101）

摘　　要：树突状细胞（DC）具有摄取、加工、处理和呈递抗原以及激活初始T淋巴细胞的功能，是体内功能最强的专职抗原递呈细胞，也是免疫应答的关键细胞。近年来研究发现，体外经肿瘤抗原刺激的DC回输到病人体内，能诱导机体产生细胞毒性T淋巴细胞，从而发挥特异性肿瘤杀伤作用。根据这一发现研制的DC疫苗目前在妇科肿瘤免疫治疗中已取得重要进展，因而受到日益广泛的关注。Dendritic cells are well known as the strongest antigen-presentation cells at present, which exert the effects of capturing, processing and presenting antigen, as well as sensitizing naive T cells. In vitro, cultureted dendritic cells stimulated by tumor antigen could induce the generation of cytotoxic T lymphocytes and lead to tumor-specific killing . Based on the finding, dendritic cells vaccine has been developed and some im- portant application progress has been gained in immunotherapy for gynecological cancers at present. Therefore, more attention is focused on dendritic cells vaccine for gynecological cancers.

关 键 词：树突状细胞 免疫治疗 肿瘤疫苗 妇科肿瘤 

分 类 号：R737[医药卫生—肿瘤]