尿酸与多发性硬化关系的研究进展  

Advances in the relationship between uric acid and multiple sclerosis

作　　者：张先龙 

机构地区：[1]类底市中心医院神经内科,417000

出　　处：《国际免疫学杂志》2011年第1期45-48,共4页International Journal of Immunology

摘　　要：多发性硬化（MS）是一种T细胞介导的自身免疫性疾病，其确切病因及发病机制尚不清楚，免疫学因素在发病中起着关键作用，其中在免疫细胞的效应阶段过氧化亚硝酸盐（ONOO-）起重要作用。尿酸是嘌呤核苷酸代谢的终产物，是内源性的抗氧化剂和过氧化亚硝酸盐的天然清除剂，在MS病人的病理损害过程中具有保护作用。MS病人的血清尿酸水平显著低于对照，且可能与疾病的活动性、病程、神经伤残程度及性别有关。尿酸及其前体物质肌苷可用于治疗MS。因此对尿酸与MS关系的研究有望进一步阐明MS发病机理并找到治疗MS的新方案。Multiple sclerosis （MS） is a T cell-mediated autoimmune disease, its etiological factors and pathogenesis are unclear. Immunological factors play a key role in MS. In the effector phase of immune cells, peroxynitrite （ONO0-） play an important role. Uric acid, the end product of purine nucleotide metabolism is an endogenous antioxidant and a natural peroxynitrite scavenger. Uric acid has the protective function in the pathological process of multiple sclerosis. Serum uric acid levels in patitents with multiple sclerosis were signifi- cantly lower than that in the control, and may be associated with the activity, duration, neurological disability, gender of MS patients. Uric acid and its precursor inosine can be used for the treatment of multiple sclerosis. The research in the relationship between uric acid＇and multiple sclerosis is expected to further expound the mechanism of multiple sclerosis and to find a new scheme of treatment cure for MS.

关 键 词：尿酸 过氧化亚硝酸盐 实验性变态反应性脑脊髓炎 多发性硬化 

分 类 号：R744.51[医药卫生—神经病学与精神病学]